Skeletal Muscle Regeneration in the Mouse Methods and Protocols
This volume focuses on the cell biology and physiology of skeletal muscle regeneration. This Book is a collection of classic and cutting edge protocols optimized for mice, but in most cases adaptable to rat or other mammalian models, that will allow an in
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Michael Kyba Editor
Skeletal Muscle Regeneration in the Mouse Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Skeletal Muscle Regeneration in the Mouse Methods and Protocols
Edited by
Michael Kyba Lillehei Heart Institute, University of Minnesota, Minneapolis, MN, USA
Editor Michael Kyba Lillehei Heart Institute University of Minnesota Minneapolis, MN, USA
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-3808-7 ISBN 978-1-4939-3810-0 (eBook) DOI 10.1007/978-1-4939-3810-0 Library of Congress Control Number: 2016948837 © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC New York
Preface Although skeletal muscle is the most abundant tissue in the body, playing key roles in metabolism, heat generation, and macromolecule storage in addition to the obvious role in locomotion, our understanding of the mechanisms underlying the growth, damage, degeneration, and repair of this tissue is still very limited. The past decade has seen rapid advances in our understanding of the development and cell biology of skeletal muscle progenitor cells and a burgeoning of laboratory research on skeletal muscle regeneration. These advances rest in large part on novel technologies and methods that, combined with new genetic tools available in the mouse model, have reshaped the field. As the field has swelled with many new investigators focused on the mouse model, there seemed a need for a volume that collects these critical protocols, optimized for mouse but in most cases easily adaptable to rat or other mammalian models. I thank my many wonderful colleagues for their contribu
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