Statins induce skeletal muscle atrophy via GGPP depletion-dependent myostatin overexpression in skeletal muscle and brow
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ORIGINAL ARTICLE
Statins induce skeletal muscle atrophy via GGPP depletion-dependent myostatin overexpression in skeletal muscle and brown adipose tissue Lai Wang & Zu-Guo Zheng & Lingchang Meng & Lijun Zhu & Ping Li & Jun Chen & Hua Yang
Received: 12 February 2020 / Accepted: 16 September 2020 # Springer Nature B.V. 2020
Abstract Myopathy is the major adverse effect of statins. However, the underlying mechanism of statininduced skeletal muscle atrophy, one of statin-induced myopathy, remains to be elucidated. Myostatin is a negative regulator of skeletal muscle mass and functions. Whether myostatin is involved in statin-induced skeletal muscle atrophy remains unknown. In this study, we uncovered that simvastatin administration increased Lai Wang and Zu-Guo Zheng contributed equally to this work. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10565-020-09558-w) contains supplementary material, which is available to authorized users. L. Wang : Z.
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