Stimuli-Responsive Polymer Materials for Creation of Biointerfaces
In this review, we introduce the biorecognition-driven stimuli-responsive surface and hydrogels. The first attention focuses on recent advances in the development of functionalizable antifouling coatings and their applications in label-free optical biosen
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Stimuli-Responsive Polymer Materials for Creation of Biointerfaces Hidenori Otsuka and Daisuke Matsukuma
Abstract In this review, we introduce the biorecognition-driven stimuli-responsive surface and hydrogels. The first attention focuses on recent advances in the development of functionalizable antifouling coatings and their applications in label-free optical biosensors. Approaches to the development of antifouling coatings, ranging from self-assembled monolayers and PEG derivatives to low-fouling polymer brushes and polymerized gels, are reviewed. Preparation of antifouling coatings and the functionalization of antifouling coatings with bioreceptors are introduced, and the application example of biofunctional coating with fouling properties is discussed. Special attention is given to biofunctional coatings for label-free bioanalysis of blood plasma and serum for medical diagnostics. The following focus is fed light on the biorecognition-based stimuli-responsive hydrogels. We will discuss on peptides and proteins recognition system of stimuli-responsive hybrid hydrogel composed of synthetic polymers and biopolymers. Keywords Biorecognition
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Stimuli-responsive hydrogel Peptide Protein
Introduction
To sustain life and maintain biological function, nature requires selectively tailored molecular assemblies and interfaces that provide a specific chemical function and structure, and which change in their environment. Synthetic polymer systems (Fig. 13.1) including copolymers and polymer composites are often prepared as two-dimensional (2D) (films) and three-dimensional (3D) (particulates and their assemblies) stimuli-responsive structures for a broad range of applications, such as drug delivery, tissue engineering, medical diagnostics, and bioseparations [1]. This H. Otsuka (&) D. Matsukuma Department of Applied Chemistry, Faculty of Science Division I, Tokyo University of Science, Tokyo, Japan e-mail: [email protected] © Springer Nature Singapore Pte Ltd. 2017 T. Kawai and M. Hashizume (eds.), Stimuli-Responsive Interfaces, DOI 10.1007/978-981-10-2463-4_13
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Fig. 13.1 ‘Galaxy’ of nanostructured stimuli-responsive polymer materials. These materials rely on the phase behavior of macromolecule assemblies in thin films (polymer brushes, multilayered films made of different polymers, hybrid systems that combine polymers and particles, thin films of polymer networks, and membranes that are thin films with channels/pores), and nanoparticles (micelles, nanogels, capsules and vesicles, core–shell particles, hybrid particle-in-particle structures, and their assemblies in solutions and at interfaces in emulsions and foams) (data from Nat. Mater. (2010), 9, 101–113)
article focuses on stimuli-responsive macromolecular nanostructures that are capable of conformational and chemical changes on receiving an external signal. These changes are accompanied by variations in the physical properties of the polymer. The signal is derived from changes in the materials’ environment, suc
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