Studies on Pediatric Disorders

This volume examines the role of oxidative stress in the pathology of numerous pediatric disorders. It covers a wide range of topics including the chemistry and biology of reactive oxygen species and nitric oxide, molecular biology of the enzymes generati

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Hirokazu Tsukahara Kazunari Kaneko Editors

Studies on Pediatric Disorders

Oxidative Stress in Applied Basic Research and Clinical Practice

Editor-in-Chief Donald Armstrong

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Note from the Editor-in-Chief All books in this series illustrate point-of-care testing and critically evaluate the potential of antioxidant supplementation in various medical disorders associated with oxidative stress. Future volumes will be updated as warranted by emerging new technology, or from studies reporting clinical trials. Donald Armstrong Editor-in-Chief

Hirokazu Tsukahara • Kazunari Kaneko Editors

Studies on Pediatric Disorders

Editors Hirokazu Tsukahara Department of Pediatrics Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama, Japan

Kazunari Kaneko Department of Pediatrics Kansai Medical University Hirakata-shi Osaka, Japan

ISSN 2197-7224 ISSN 2197-7232 (electronic) ISBN 978-1-4939-0678-9 ISBN 978-1-4939-0679-6 (eBook) DOI 10.1007/978-1-4939-0679-6 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2014937525 © Springer Science+Business Media, LLC 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is a brand of Springer Springer is part of Springer Science+Business Media (


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