• PDF / 9,637,458 Bytes
• 587 Pages / 439.37 x 666.142 pts Page_size
• 118 Downloads / 179 Views

DOWNLOAD

REPORT

---

Editor-in-Chief Donald Armstrong

For other titles published in this series, go to http://www.springer.com/series/8145

Note from the Editor-in-Chief All books in this series illustrate point-of-care testing and critically evaluate the potential of antioxidant supplementation in various medical disorders associated with oxidative stress. Future volumes will be updated as warranted by emerging new technology, or from studies reporting clinical trials. Donald Armstrong Editor-in-Chief

Heinrich Sauer · Ajay M. Shah · Francisco R.M. Laurindo Editors

Studies on Cardiovascular Disorders

Editors Heinrich Sauer Universität Gießen Physiologisches Institut Aulweg 129 35392 Gießen Germany [email protected]. unigiessen.de

Ajay M. Shah King’s College London James Black Centre Coldharbour Lane 125 SE5 9NU London King’s Denmark Hill Campus United Kingdom [email protected]

Francisco R.M. Laurindo Universidade of São Paulo Fac. Medicina Instituto do Coração (INCOR) Lab. Biologia Molecular Av. Enéas de Carvalho Aguiar 44 05403-000 São Paulo, São Paulo Subsolo Brazil [email protected]

ISBN 978-1-60761-599-6 e-ISBN 978-1-60761-600-9 DOI 10.1007/978-1-60761-600-9 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010934121 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)

Preface

The role of reactive oxygen species (ROS) in the cardiovascular system is Janusfaced. Whereas low concentrations of ROS are involved in variety of physiological signalling events, oxidative stress resulting from deregulated overproduction of ROS and/or impaired antioxidant defences contributes to cardiovascular disease. The actions of ROS in the cardiovascular system are a fascinating topic, not only for the basic science researcher but also for the clinician who is interested in seeking new therapies for his patients suffering from cardiovascular disease. The current book provides a comprehensive overview of the molecular mechanisms and pathophysiological settings in which chronic and detrimental oxidative stress arises within the heart and vasculature. The book also considers currently discussed strategies in avoiding chronic redox stress resulting from exposure to