Systemic Vasculitides: Current Status and Perspectives
The systemic vasculitides,includinglarge, medium, small, and variable vessel vasculitis,have been the focus of intensive basic and clinical investigations over the last twodecades. Among theimportant advances stemming from these efforts are new definition
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temic Vasculitides: Current Status and Perspectives
Systemic Vasculitides: Current Status and Perspectives
Franco Dammacco • Domenico Ribatti Angelo Vacca Editors
Systemic Vasculitides: Current Status and Perspectives
Editors Franco Dammacco University of Bari Medical School Bari, Italy
Domenico Ribatti University of Bari Medical School Bari, Italy
Angelo Vacca University of Bari Medical School Bari, Italy
ISBN 978-3-319-40134-8 ISBN 978-3-319-40136-2 DOI 10.1007/978-3-319-40136-2
(eBook)
Library of Congress Control Number: 2016954956 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
To be fully aware of one’s own ignorance is an irrepressible incitation to the pursuit of knowledge.
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Preface
This volume seeks to provide a comprehensive overview of the systemic vasculitides, an extremely heterogeneous group of diseases characterized by inflammation and necrosis of different-sized blood vessels. With a few exceptions (e.g., HCVrelated cryoglobulinemic vasculitis and HBV-positive polyarteritis nodosa), the etiology of these clinical conditions remains unknown. In spite of their relatively low prevalence, the systemic vasculitides have been the object of recent, intensive, basic, and clinical studies. For this reason, it can be safely stated that this group of diseases is one of the most rapidly progressing areas of clinical medicine, as evidenced by the dramatic achievements in terms of clinical remission and overall prognostic improvement. The pathophysiology of the vasculitides is multifactorial and thus in most cases poorly defined. Among the many potential influences on disease expression, sex, ethnicity, and genetic as well as environmental factors are likely to play a role. In addition, the vascular damage characteristic of the systemic vasculitides ma
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