Systems Biology The Challenge of Complexity
Biological signaling pathways dynamically interact with one another to form complex information networks intracellularly, intercellularly, and eventually at the level of the organism. Biology and medicine have conventionally focused on identification and
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Shigetada Nakanishi Dai Watanabe
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Ryoichiro Kageyama
Editors
Systems Biology The Challenge of Complexity
Editors Shigetada Nakanishi, M.D., Ph.D. Director Osaka Bioscience Institute Osaka 565-0874 Japan
Ryoichiro Kageyama, M.D., Ph.D. Director, Professor Institute for Virus Research Kyoto University Kyoto 606-8507 Japan
Dai Watanabe, M.D., Ph.D. Professor Department of Biological Sciences Faculty of Medicine, and Department of Molecular and System Biology Graduate School of Biostudies Kyoto University Kyoto 606-8501 Japan
ISBN: 978-4-431-87703-5 Springer Tokyo Berlin Heidelberg New York e-ISBN: 978-4-431-87704-2 DOI: 10.1007/978-4-431-87704-2 Library of Congress Control Number: 2009922675 © Springer 2009 Printed in Japan This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Printed on acid-free paper Springer is a part of Springer Science + Business Media springer.com
Preface
Biological signaling pathways dynamically interact with one another to form complex information networks intracellularly, intercellularly, and eventually at the level of the organism. Biology and medicine have conventionally focused on identification and characterization of functional elements in biological signaling pathways. Recently, research in this field has been pursuing a new approach, systems biology, to understand the dynamics, complexity, and physiological functions of the biological signaling networks. Instead of reductionistic analyses or large-scale studies of biomolecules piece by piece, systems biology emphasizes the need for interdisciplinary methods and analysis of the regulation and operation of information networks at the systems level. The Uehara Memorial Symposium 2008, entitled “Systems Biology: The Challenge of Complexity,” was convened in Tokyo from June 30 to July 2, 2008. The aim of the symposium was to bring together leading scientists in the field of systems biology to discuss the latest research on function and dysfunction of biological networks. The following are the main topics addressed in the symposium: 1. Dynamics and complexity of intercellular networks 2. Integrative mechanism of intracellular information networks 3. Dysfunction of information networks and related diseases An explicit aim of the symposium was to contribute to an understanding of the complexity and dynamics of biological systems and to direct our efforts toward the development of novel strategies for disease control. We are very pleased to be able to publish the proceedings of this exciting symposium. Osaka, Japan
Shigetada Nakanishi, Editor
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