Teratocarcinoma-derived growth factor-1 (Cripto-1) is overexpressed in epithelial odontogenic lesions displaying more ag
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ORIGINAL ARTICLE
Teratocarcinoma-derived growth factor-1 (Cripto-1) is overexpressed in epithelial odontogenic lesions displaying more aggressive behaviour Leorik Pereira da Silva 1,2 & Mara Luana Batista Severo 1 & Luiz Arthur Barbosa da Silva 1 Hébel Cavalcanti Galvão 1 & Lélia Batista de Souza 1 & Márcia Cristina da Costa Miguel 1
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Received: 30 April 2020 / Accepted: 29 June 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose Cripto-1 also known as teratoma-derived growth factor 1 (TDGF-1) belongs to the EGF-CFC family of growth factorlike molecules. Cripto-1 is involved with embryonic development and not expressed in adult tissue, but some tumours are accompanied by reactivation. Methods The aim of this study was to evaluate the immunohistochemical expression of Cripto-1 in most common odontogenic cysts and tumours. Thirty ameloblastomas, 30 keratocysts, 30 dentigerous cysts and two ameloblastic carcinomas were evaluated using the polymeric immunoperoxidase technique. Immunohistochemical expressions were analysed by the IRS (immunoreactive score). Statistical analyses were performed by the Kruskal–Wallis and Mann–Whitney tests (p ≤ 0.05). Results Age ranged from 9 to 75 years old, with a prevalence of females (n = 49/53.3%). The mandible was the most affected anatomical site (n = 69/75.0%). Cripto-1 immunoexpression was observed in all ameloblastoma, keratocyst and ameloblastic carcinoma cases, although nine dentigerous cyst cases (30%) were negative. Expression scores were higher in ameloblastoma, keratocyst and ameloblastic carcinoma cases (median ranging from 8 to 11) when compared with dentigerous cyst cases (median of 2), with a statistically significant difference (p < 0.001). Conclusions Cripto-1 is critically important in the progression of several tumours since it is related to significant cell survival and differentiation pathways. The high expression of Cripto-1 in more aggressive odontogenic lesions suggests that this molecule may be involved in the activation of important pathways related to the etiopathogenesis of these lesions. Keywords Odontogenic tumours . Odontogenic cysts . Biological marker . Cripto-1
Introduction Odontogenic lesions constitute a complex group of neoplasias and cysts located in the maxillofacial complex, presenting cytological diversity and differential architectural patterns characteristic of each lesion. Concerning the neoplasm group, ameloblastomas (AMB) are the most frequently diagnosed,
* Leorik Pereira da Silva [email protected] 1
Oral Pathology, Department of Dentistry, Federal University of Rio Grande do Norte-UFRN, Av. Sen Salgado Filho, 1787, Lagoa Nova, Natal, RN, Brazil
2
Institute of Health and Biotechnology, Federal University of Amazonas-UFAM, Coari, AM, Brazil
accounting for 35–45% of all odontogenic neoplasms in this region [1]. This type of tumour presents a slow growth and maybe locally aggressive, sometimes causing large bone destruction areas and presenting high local recurrence rates, leading to extensive and mu
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