The decreased mean platelet volume is associated with poor prognosis in patients with oropharyngeal cancer treated with
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RESEARCH
The decreased mean platelet volume is associated with poor prognosis in patients with oropharyngeal cancer treated with radiotherapy Daniela Delago1, Olivia Knittelfelder1, Gabriele Jakse1, Katarzyna Lukasiak1, Sabine Reinisch2, Wilfried Renner3, Heidi Stranzl‑Lawatsch1, Richard Partl1* and Tanja Langsenlehner1
Abstract Background: There is considerable evidence that platelets contribute to cancer growth and metastatic dissemina‑ tion. In recent studies, altered mean platelet volume (MPV) has been associated with prognosis in different types of cancer. However, the prognostic role of the MPV in head and neck squamous cell cancer (HNSCC) is currently dis‑ cussed controversially. The present study was performed to analyze and further elucidate the prognostic significance of the MPV in HNSCC. Methods: A total of 319 oropharyngeal squamous cell cancer (OPSCC) patients treated with radiotherapy at a ter‑ tiary academic center were enrolled in the present study. Kaplan–Meier method as well as uni- and multivariate Cox proportional hazards were used to evaluate the impact of MPV on cancer-specific survival (CSS), locoregional control (LC) and recurrence-free survival (RFS). Results: The median MPV was 10.30 fL (mean 10.26 ± 1.17fL). Univariate analyses showed a significant association of the MPV with CSS (HR 0.85, 95% CI 0.74–0.98, p = 0.025), LC (HR 0.86, 95% CI 0.74–0.99, p = 0.034) and RFS (HR 0.87, 95% CI 0.76–0.996; p = 0.043). In multivariate analysis, the MPV remained an independent prognostic factor for CSS (HR 0.77, 95% CI 0.63–0.93, p = 0.008), LC (HR 0.80, 95% CI 0.65–0.98, p = 0.030), and RFS (HR 0.83, 95% CI 0.685–0.999, p = 0.049). Conclusions: Our findings indicate that the MPV is a prognostic marker in OPSCC patients and may contribute to future individual risk assessment. Keywords: Oropharyngeal cancer, Biomarker, Mean platelet volume, Prognostic factor, Outcome Background Oropharyngeal squamous cell carcinoma (OPSCC) is a common malignancy of the head and neck and includes cancers of the tonsils, base of the tongue, soft palate, and *Correspondence: [email protected] 1 Department of Therapeutic Radiology and Oncology, Comprehensive Cancer Center, Medical University of Graz, Auenbruggerplatz 32, 8036 Graz, Austria Full list of author information is available at the end of the article
upper lateral and posterior pharyngeal walls. Worldwide age-adjusted incidence rates for men and women are 3.8 and 0.8 per 100 000 populations respectively, with a substantial variation in different regions and countries [1, 2] Despite several advances in the management of OPSCC including novel imaging as well as innovations in surgical and radiotherapeutic techniques, the overall survival of patients with OPSCC still remains around 50% at 5 years, primarily because of locoregional and/or systemic recurrence of disease [2]. In recent years, many efforts have
© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which
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