Matrix Metalloproteases Methods and Protocols
Since the identification of the first matrix metalloprotease (insterstitial collagenase or MMP-1) more than 20 closely related and evolutionarily conserved vertebrate MMPs have been discovered. Chapters in this volume detail methods and protocols on recen
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Charles A. Galea Editor
Matrix Metalloproteases Methods and Protocols
Methods
in
Molecular Biology
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Matrix Metalloproteases Methods and Protocols
Edited by
Charles A. Galea Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia
Editor Charles A. Galea Drug Delivery, Disposition and Dynamics Monash Institute of Pharmaceutical Sciences Monash University Parkville, VIC, Australia
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-6861-9 ISBN 978-1-4939-6863-3 (eBook) DOI 10.1007/978-1-4939-6863-3 Library of Congress Control Number: 2017930809 © Springer Science+Business Media LLC 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface The matrix metalloprotease (MMP) field has witnessed enormous advances since Jerome Gross and Charles Lapière first observed in 1962 an enzymatic activity (collagen degradation) associated with tadpole tail metamorphosis. Since the identification of this enzyme (interstitial collagenase or MMP-1), more than 20 closely related and evolutionarily conserved vertebrate MMPs have been discovered. These MMPs and their endogenous inhibitors (TIMPS) are involved in a diverse range of functions including tissue remodeling, immunity, inflammation, and angiogenesis. The first part of this book outlines recent advances in the expression and purification of MMPs in various expression systems, highlighti
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