The impact of cyclin D1 overexpression on the prognosis of bladder cancer: a meta-analysis
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WORLD JOURNAL OF SURGICAL ONCOLOGY
RESEARCH
Open Access
The impact of cyclin D1 overexpression on the prognosis of bladder cancer: a meta-analysis Baoming Ren1, Wenjun Li1, Yanping Yang2 and Songdi Wu3*
Abstract Background: To evaluate the relationship between cyclin D1 overexpression and bladder cancer prognosis. Methods: A systematic literature search up to July 27, 2013 was carried out in PubMed and Wanfang databases, and the references of retrieved articles were screened. The hazard ratios (HRs) and their 95% CIs were used to combine the data. Heterogeneity and publication bias were also evaluated. Results: A total of 15 studies containing 2,591 cases were included. We found that increased cyclin D1 levels were significantly correlated with progression-free survival with a pooled HR estimate of 0.54 (95% CI: 0.32–0.92). There was a significant degree of heterogeneity (I2 = 93.8%, P
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