Cyclin D1 overexpression and poor clinical outcomes in Taiwanese oral cavity squamous cell carcinoma
- PDF / 491,168 Bytes
- 7 Pages / 595.28 x 793.7 pts Page_size
- 99 Downloads / 207 Views
WORLD JOURNAL OF SURGICAL ONCOLOGY
RESEARCH
Open Access
Cyclin D1 overexpression and poor clinical outcomes in Taiwanese oral cavity squamous cell carcinoma Shiang-Fu Huang1†, Sou-De Cheng2†, Wen-Yu Chuang3, I-How Chen1, Chun-Ta Liao1, Hung-Ming Wang4 and Ling-Ling Hsieh5*
Abstract Background: Cyclin D1 gene regulates cell cycle and plays an important role in the tumorigenesis of human cancers. The association between cyclin D1, clinicopathologic parameters and prognosis in oral cavity squamous cell carcinoma (OSCC) is inconclusive. Methods: A total of 264 male OSCCs were examined for cyclin D1 protein expression using immunohistochemistry (IHC). The expression levels of cyclin D1 were defined as overexpression when more than 10% of tumor cells displayed nuclear staining with moderate to strong intensity. Results: Overexpression of cyclin D1 was found in 97 (36.7%) OSCCs. Cyclin D1 protein overexpression was significantly associated with lymph node metastasis (P = 0.002), tumor cell differentiation (P = 0.031) and tumor stage (P = 0.051), but not associated with age onset, cigarette smoking, alcohol drinking, or areca quid chewing. Overexpression of cyclin D1 was also significantly associated with poor clinical outcomes in terms of disease-free survival (DFS, P = 0.002) and overall survival (OS, P < 0.001). The effects of cyclin D1 protein overexpression on DFS (hazard ratio (HR) = 1.540; 95% confidence interval (CI), 1.068 - 2.222) and OS (HR = 1.702; 95% CI, 1.168 - 2.480) were still existed after adjusting for clinicopathological paremeters (such as age, primary tumor status, tumor cell differentiation, and lymph node metastasis) using logistic multivariate analysis. Conclusion: Cyclin D1 protein worked as an independent prognostic factor and can be as a biomarker for the aggressiveness of OSCC. Keywords: oral squamous cell carcinoma, lymph node metastasis, cyclin D1
Background In Taiwan, oral cancer is the fourth most common cancer in men [1]. Epidemiologic studies have shown that environment and personal habits, particularly tobacco use, areca quid (AQ) chewing and alcohol abuse, are major etiologic factors in the induction and progression of this disease. About two thirds of oral cancers were occurred in oral cavity. The primary treatment for oral cavity squamous cell carcinoma (OSCC) is radical surgery with or without post-operative chemoradiation [2]. However, for patients with tumors at advanced stage, * Correspondence: [email protected] † Contributed equally 5 Department of Public Health, Chang Gung University, Tao-Yuan, Taiwan Full list of author information is available at the end of the article
their prognoses are usually discouraging. If we can better understand the characteristics of OSCCs, this may ultimately help clinicians to provide OSCC patients with more appropriate treatment. The cyclin D1 gene (CCND1) located on chromosome 11q13 is a positive regulator of the cell cycle. It encodes a nuclear protein that forms complexes with cyclin-dependent kinases 4 and 6, which phosphorylate an
Data Loading...
