The research of aptamer biosensor technologies for detection of microorganism
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MINI-REVIEW
The research of aptamer biosensor technologies for detection of microorganism Jiecan Yi 1,2 & Wen Xiao 3 & Guiyin Li 4 & Pian Wu 1 & Yayuan He 1 & Cuimei Chen 1 & Yafei He 1 & Ping Ding 1 & Tianhan Kai 5 Received: 21 May 2020 / Revised: 27 September 2020 / Accepted: 1 October 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract The activities and transmissions of microorganisms are closely related to human, and all kinds of diseases caused by pathogenic microorganisms have attracted attention in the world and brought many challenges to human health and public health. The traditional microbial detection technologies have characteristics of longer detection cycle and complicated processes, therefore, which can no longer meet the detection requirements in the field of public health. At present, it is the focus to develop and design a novel, rapid, and simple microbial detection method in the field of public health. Herein, this article summarized the development of aptamer biosensor technologies for detection of microorganism in the aspect of bacteria, viruses, and toxins in detail, including optical aptamer sensors such as fluorometry and colorimetry, electrochemical aptamer sensors, and other technologies combined with aptamer. Key points • Aptamer biosensor is a good platform for microbial detection. • Aptamer biosensors include optical sensors and electrochemical sensors. • Aptamer sensors have been widely used in the detection of bacteria, viruses, and other microorganisms. Keywords Aptamer . Pathogenic bacteria . Optical sensors . Electrochemical sensors . Detection
Introduction Microorganisms mainly include bacteria, viruses, fungi, and a small number of algae, which are widely distributed in the environment and closely related to human activities. Some * Ping Ding [email protected] * Tianhan Kai [email protected] 1
Xiang Ya School of Public Health, Central South University, Changsha 410078, Hunan, China
2
School of Public Health, Changsha Medical University, Changsha 410219, Hunan, China
3
Hunan Institute of Food Quality Supervision Inspection and Research, Changsha 410000, Hunan, China
4
School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin 541014, Guangxi, China
5
College of Chemistry and Chemical Engineering, Central South University, Changsha 410078, Hunan, China
microorganisms are beneficial to human health. For example, probiotics can promote intestinal absorption (Lu et al. 2019; He et al. 2019). While some microorganisms are harmful to human health like pathogenic bacteria can cause human diseases. For instance, Staphylococcus aureus (S. aureus) and its enterotoxin are a major cause of food poisoning (Wu et al. 2016). Salmonella can cause gastroenteritis and typhoid fever (Gasem et al. 1995; Mccormick et al., 1996). Helicobacter pylori (H. pylori) may induce peptic ulcer and gastric lymphoma (Cheng et al., 2017a). All kinds of influenza virus such as H5N1, H1N1, and H9N2 infect the human body, causing severe illne
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