The value of melatonin supplementation in postmenopausal women with Helicobacter pylori -associated dyspepsia
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The value of melatonin supplementation in postmenopausal women with Helicobacter pylori‑associated dyspepsia Cezary Chojnacki, Marta Mędrek‑Socha, Paulina Konrad, Jan Chojnacki and Aleksandra Błońska*
Abstract Background: Dyspeptic syndrome is particularly common in postmenopausal women in the form of epigastric pain. The aim of the study was to assess the role of melatonin in chronic dyspepsia in this group of women, and examine the role of Helicobacter infection. Methods: The study comprised 152 subjects including 30 healthy women (Group I), 60 women with asymptomatic H.pylori infection (Group II), and 64 women with H. pylori infection with chronic dyspepsia (Group III). Endoscopic examination was performed, as well as histological assessment of gastric end duodenal mucosa, urease breath test (UBT-13C), and immunoenzymatic assessment of serum 17-β-estradiol, follicle stimulating hormone and melatonin, and urinary 6-sulfatoxymelatonin. In Group III, 14-day antibacterial treatment was introduced with pantoprazole, amoxicillin and levofloxacin followed a six-month treatment with placebo in 32 women (Group IIIa), and melatonin 1 mg/morning and 3 mg/at bedtime in the other 32 women (Group IIIb). Results: No significant differences were found between serum level of female hormone. Serum melatonin levels were similar between Group I (12.5 ± 2.72 pg/ml) and Group II (10.5 ± 3.73 pg/ml; p > 0,05). The level was significantly lower in Group III (5.72 ± 1.42 pg/ml; p 0.05). After six months, dyspeptic symptoms resolved in 43.7% patients in Group IIIa and 84.3% in Group IIIb (p 0.05
Fig. 1 The serum level of 17-β-estradiol in healthy women (Group I), in women with asymptomatic H. pylori infection (Group II) and in women with both H. pylori infection and chronic dyspepsia (Group III); no significant differences were observed between groups (p > 0.05)
Statistical analysis
Normally distributed data was compared using Student’s t-test, and non-normal data by the Kruskal–Wallis and post hoc tests. Data were expressed as mean and standard deviation. Therapeutic effects after melatonin supplementation were evaluated using the chi-square test. A p value of 0.05). However lower levels were found in women with symptomatic H. pylori infection: 5.27 ± 1.42 pg/ml (p 0.05)
Fig. 3 The serum level of melatonin in healthy women (Group I), in women with asymptomatic H. pylori infection (Group II), and in women with both H. pylori infection and chronic dyspepsia (Group III); differences between groups I and II (p > 0.05), I and III (p
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