Thin-layer chromatographic analysis of mangiferin (a bioactive antioxidant from dietary plant sources): a mini-review
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Thin-layer chromatographic analysis of mangiferin (a bioactive antioxidant from dietary plant sources): a mini-review Sushil Kumar Chaudhary 1
&
Vaibhav Walia 1
&
Vijay Singh 1 & Neeraj K. Sethiya 1
Received: 17 April 2020 / Accepted: 13 July 2020 # Akadémiai Kiadó, Budapest, Hungary 2020
Abstract The thin-layer chromatographic (TLC) analysis of extracts/compounds has several applications in the field of food, cosmetics, phytochemistry, and pharmaceutical industry. Mangiferin is a bioactive and natural antioxidant polyphenolic xanthone obtained from different dietary plants and recently gaining remarkable attention due to its high pharmacological significance evident in current scientific validations. This review contains various TLC methods reported so far for the qualitative and quantitative assessments of mangiferin after collating selected research papers from online scientific databases as PubMed, Web of Science, and Scopus. In particular, confirmation of mangiferin from dietary plant, herbal formulations, and biological and bioautographic samples through TLC are discussed in detail and comparison is also established in terms of selectivity, sensitivity, and validity. Ultimately, critical evaluation was done with the aim to deliver useful suggestions for the selection of suitable mobile phase, sample preparation, and detection methods for the analysis of mangiferin. Keywords TLC . Mangiferin . HPTLC . Method development . Solvent selection . Mobile phase
1 Introduction Dietary xanthones are natural polyphenolic compounds mainly consisting of polyhydroxylated nucleus along with several other functional groups in three-ring systems [1]. Among xanthones, aryl-C-glycosides (C–C bonds) are the most suitable candidates of drug, as they exhibit a wide range of biological properties and possess remarkable stability toward both enzymatic and chemical hydrolysis [2]. Mangiferin (2-C-β-Dglucopyranosyl-1,3,6,7-tetrahydroxyxanthone; Fig. 1), is the first xanthone to be investigated for pharmacological purposes, which is found to be present in various fruits; vegetables; medicinal plants; teas and coffee; and plants such as mango, honeybush, mango ginger, and shankhpushpi [3–5]. Physiologically, moderate aqueous solubility (1.44 mg/mL), and lower lipophilicity (− 0.59) of mangiferin were predicted earlier by in silico simulations [6]. Biologically, mangiferin (phenolic xanthone) protects from reactive oxygen species (ROS)-induced oxidative stress through free radical
* Neeraj K. Sethiya [email protected] 1
Faculty of Pharmacy, DIT University, Mussoorie Diversion Road, Dehradun, Uttarakhand 248009, India
scavenging effects [7, 8]. Moreover, scientific literature shows that mangiferin also possesses analgesic, antiviral, antisclerotic, immunomodulatory, cardioprotective, adaptogenic, cognition boosting, antimicrobial, antiparasitic, antiallergic, anticancer, antidiabetic, antiasthmatic, antialzheimer, hepatoprotective, antiseptic, radioprotective (X-ray, gamma, and UV radiation), antiinflammato
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