Tissue engineering stent model with long fiber-reinforced thermoplastic technique
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ENGINEERING AND NANO-ENGINEERING APPROACHES FOR MEDICAL DEVICES Original Research
Tissue engineering stent model with long fiber-reinforced thermoplastic technique Mei-Chen Lin1 Jia-Horng Lin2,3,4,5,6,7,8 Chih-Yang Huang9,10,11,12 Yueh-Sheng Chen ●
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Received: 23 April 2020 / Accepted: 12 July 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract This study aims to construct tissue engineering stents by using the long fiber-reinforced thermoplastic (LFT) technique to develop artery stents. The experimental method combines fibers, the LFT technique, and electrospinning technique. First, the biodegradable polyvinyl alcohol yarns are twisted and coated in polycaprolactone/polyethylene glycol blends through the LFT technique. Next, the weft-knitting and heat treatment are used to establish the stent structure, after which poly (ethylene oxide) (PEO) is electrospun to coat the stents. The morphology, mechanical, and biological properties of tissue engineering stents are evaluated. The test results indicated that the use of the LFT technique retains the softness of filaments, which facilitates the subsequent weft-knitting process. The coating of blends and electrospinning of PEO have a positive influence on the tissue engineering stents, as demonstrated by the tensile strength of 59.93 N and compressive strength of 6.10 N. Moreover, the in vitro degradation of stents exhibits a stabilized process. The water contact angle is 20.33°, and the cell survival rate in 24 h is over 80%. The proposed tissue engineering stents are good candidates for artery stent structure.
* Yueh-Sheng Chen [email protected] 1
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Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, ROC
Laboratory of Fiber Application and Manufacturing, Department of Fiber and Composite Materials, Feng Chia University, Taichung, Taiwan, ROC
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Fujian Key Laboratory of Novel Functional Textile Fibers and Materials, Minjiang University, Fuzhou, China
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan, ROC
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Innovation Platform of Intelligent and Energy-Saving Textiles, School of Textiles, Tiangong University, Tianjin, China
Department of Biotechnology, Asia University, Taichung, Taiwan, ROC
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College of Textile and Clothing, Qingdao University, Shangdong, China
Holistic Education Center, Tzu Chi University of Science and Technology, Hualien, Taiwan, ROC
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Cardiovascular and Mitochondria Related Diseases Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan, ROC
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School of Chinese Medicine, China Medical University, Taichung, Taiwan, ROC
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Department of Fashion Design, Asia University, Taichung, Taiwan, ROC
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School of Chinese Medicine, China Medical University, Taichung, Taiwan, ROC
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Tianjin and Ministry of Education Key Laboratory for Advanced Textile Composite Materials, Tiangong University, Tianjin, China
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