Tissue Restoration Through Regenerative Biology and Medicine
The cost of tissue damage due to degenerative disease and injury is enormous in terms of health care costs, lost economic productivity, diminished quality of life and premature death. Advances in cell, developmental and molecular biology, and the discover
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Vol. 176
Editors F. Beck, Melbourne B. Christ, Freiburg W. Kriz, Heidelberg E. Marani, Leiden W. Kummer, GieBen R. Putz, Munchen Y. Sano, Kyoto T. H. Schiebler, Wurzburg K. Zilles, Dusseldorf
Springer Berlin Heidelberg New York Hong Kong London Milan Paris Tokyo
D.L. Stocum
Tissue Restoration Through Regenerative Biology and Medicine
With 3 Figures
Springer
David L. Stocum, M.D. Department of Biology and Indiana University Center for Regenerative Biology and Medicine School of Science Indiana University - Purdue University Indianapolis 402 N. Blackford St. Indianapolis, IN 46202 USA e-mail: [email protected]
Library of Congress Cataloging-in-Publication Data Stocum, David L. Tissue restoration through regenerative biology and medicine I D.L. Stocum. p. cm. - (Advances in anatomy, embryology, and cell biology; 176) Includes bibliographical references and index. 1. Regeneration (Biology) 2. Transplantation of organs, tissues, etc. 3. Neural stem cells-Regeneration. I. Title. II. Series.
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Preface
Regenerative biology and medicine is a rapidly developing field that has emerged from research in cell and developmental biology. Regenerative biology seeks to understand the molecular mechanisms that distinguish regeneration from fibrosis by comparative analyses of regeneration-competent vs regeneration-deficient tissues, using a wide range of experimental systems, from invertebrates such as planaria through amphibians to mammals. Regenerative medicine seeks to use this understanding to induce the regeneration of regeneration-deficient tissues. Currently, we are far from the depth of understanding of natural regeneration required for its translation into a regenerative medicine. Thus, the aim of this monograph is three-fold: (1) to summarize the current state of knowledge about the mechanisms of regeneration in some
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