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wo Heteroligand Cd(II)-Coordination Polymers: Crystal Structures and Anti-Lung Cancer Activity Evaluation C. H. Yea, G. Chenb, and Y. L. Gongc, * aDepartment

of Oncology, Bazhong Central Hospital, Bazhong, Sichuan, P.R. China Department of Obstetrics and Gynecology, The Public Health Clinical Center of Chengdu, Chengdu, Sichuan, P.R. China c Department of Neurology, Affiliated Sichuan Provincial Rehabilitation Hospital of Chengdu University of TCM, Chengdu, Sichuan, P.R. China *e-mail: [email protected]

b

Received October 16, 2019; revised November 6, 2019; accepted November 28, 2019

Abstract—Two new Cd(II) containing coordination polymers, namely {[Cd(Dib)(1,4-Ndc)] · H2O}n (I, Dib = 1,4di(1H-imidazol-1-yl)butane, 1,4-H2Ndc =  naphthalene-1,4-dicarboxylic acid) and [Cd(2,2′-Dsb)-(Dpe)(DMF)(H2O)] (II, 2,2′-H2Dsb = 2,2′-disulfanediyldibenzoic acid, Dpe = (E)-1,2-di(pyridin-4-yl)ethene), have been successfully prepared under the hydrothermal or solvothermal conditions by using the carboxylic acid and Ndonor linkers with different functional groups as the co-ligands. Furthermore, the CCK-8 assay was performed to detect the inhibitory effect of these two synthetic complexes on the NCI-H292 lung cancer cell line. The mechanism of the complexes anti-cancer activity was explored with Annexin V-FITC/PI apoptosis detection and western blot assay. Keywords: coordination polymers, mixed-ligand approach, diamond-like network, anti-cancer activity DOI: 10.1134/S1070328420090080

INTRODUCTION Structure and design of metal-involved coordination polymers composed of metal ion/clusters and organic ligands with the guide of crystal engineering are currently of interest in the field of supramolecular chemistry and coordination chemistry [1–3]. The increasing interest in this field is justified not only by their valuable unit structure, but also their potential applications in luminescence, catalysis and biochemistry particularly in modern medicinal chemistry [4– 6]. Among the series of compounds fabricated, the functional complexes attract great attention due to the potential drug value applications [7–10]. Thus, selecting safe, efficient and biocompatible ligands has become a crucial factor in the field of structural design, drug therapy and clinical applications. Polydentate ligands such as polycarboxylic acids or nitrogen-containing heterocyclic ligands are widely used in the rational design and controlled synthesis of these multifunctional complexes. Recently, N-heterocyclic carboxylate ligands have attracted considerable attention of chemists and biologists because of their abundant coordination modes and functional properties, as well as hydrogen-bonding donors and acceptors under solution conditions. It is well known that carboxyl groups can possess potential coordination sites to adopt various coordination modes and the C=O groups can act as O-donors [11]. Furthermore,

ligands containing N-donor and polycarboxylic moieties are often used for constructing coordination complexes because of their better binding ability wit