STRUCTURAL INSIGHTS AND ANTI-COLON CANCER ACTIVITY OF TWO Zn(II)-BASED COORDINATION POLYMERS BASED ON CARBOXYLATE AND IM

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STRUCTURAL INSIGHTS AND ANTI-COLON CANCER ACTIVITY OF TWO Zn(II)-BASED COORDINATION POLYMERS BASED ON CARBOXYLATE AND IMIDAZOLE CO-LIGANDS Y. Yang1, P. Li2*, and S.-H. Li3

Two new mixed-ligand coordination polymers [Zn(bdc)(bib)]n (1, H2bdc = 1,3-dicarboxybenzene, bib = 1,3bis(imidazol-1-yl)benzene) and [Zn(NH2-bdc)(bib)]n (2, NH2–H2bdc = 2-amino-1,4-dicarboxybenzene) are successfully prepared by the reaction of zinc nitrate, N-containing and dicarboxylate ligands under the same hydrothermal conditions. The anti-viability of compounds 1 and 2 is assessed with CCK-8 against SW480 colon cancer cells. To further explore the underlying mechanism of compounds, the cell apoptosis and ROS detection are performed in this experiment. DOI: 10.1134/S0022476620070161 Keywords: coordination polymer, mixed-ligand, X-ray, colon cancer cell.

INTRODUCTION Cancer is the second leading cause of human death after cardiovascular and cerebrovascular diseases, especially in the developing and the undeveloped countries. According to the article published in the CA magazine “Global Cancer Statistics, 2012”, there were 14 million new cancer cases in the world in 2012 [1]. Metal complexes constitute an important class of compounds of biological interest because of their natural propensity to interact with DNA [2]. Due to their cationic characteristics, a wide spectrum of ligands, a broad range of structural geometries and electronic properties as well as kinetic properties and mechanisms of drug action, metal complexes have been widely studied and potentially used in gene regulation, probing of DNA specific structures and interactions, and the design of therapeutic agents [3-5]. As a unique class of crystalline materials constructed via self-assembly of metal ions/clusters and organic ligands, coordination polymers (CPs) have rapidly emerged in chemistry and materials science due to their new topological structures as well as versatile potential applications such as gas storage/separation, catalysis, magnetism, optics, and chemical sensing [6-10]. However, the rational design and synthesis of CPs with targeted properties and functionality have been a challenge for the synthetic chemistry. In general, the self-assembly of well-designed metal ions/clusters nodes and organic ligands is one of the most effective and available methods for preparing targeted CPs. Among various organic ligands, aromatic dicarboxylates and bis(imidazolyl)-substituted ligands are common linkers for constructing CPs [11-13]. The construction of CPs with the

1

Department of Gastrointestinal and Abdominal Hernia Surgery, People's Hospital of Jinxiang County, Jinxiang, Shandong, P. R. China. 2Department of General Surgery, The Seventh People's Hospital of Chongqing, Chongqing, P. R. China; *[email protected]. 3Department of Medicine, Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, P. R. China. Original article submitted October 8, 2019; revised November 26, 2019; accepted January 16, 2020. 1124

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