• PDF / 1,560,701 Bytes
• 7 Pages / 612 x 792 pts (letter) Page_size
• 41 Downloads / 180 Views

DOWNLOAD

REPORT

---

TWO Co(II) AND Zn(II) COORDINATION POLYMERS: STRUCTURAL CHARACTERIZATION AND ANTICANCER ACTIVITY AGAINST NASOPHARYNGEAL CARCINOMA Z.-X. He1, Z.-H. Zhang2, Y.-F. Dong1, H.-G. Liu1, S.-D. Sun1, and S.-Z. Wang3*

By employing a mixed-ligand strategy, two new coordination polymers with the chemical formulae [Co(4bptzh)(1,3-BDC)] (1) and [Zn(4-bptzp)(1,3-BDC)]n (2) are hydrothermally synthesized using two flexible bis(pyridyl-tetrazole) ligands (4-bptzh = 1,4-bis(5-(4-pyridyl)tetrazolyl)hexane, 4-bptzp = 1,4-bis(5-(4pyridyl)tetrazolyl)propane) and 1,3-benzenedicarboxylic acid (1,3-H2BDC). Both complexes are characterized by single crystal X-ray diffraction along with the elemental analysis. Furthermore, the inhibitory effect of compounds 1 and 2 against CNE-1 nasopharyngeal cancer cells are evaluated in vitro. Firstly, the antiproliferation activity of compounds 1 and 2 against cancer cells is assessed by the CCK-8 assay. Then, the cancer cell apoptosis is measured with the Annexin V-FITC/PI apoptosis assay by flow cytometry. DOI: 10.1134/S0022476620090152 Keywords: coordination polymer, X-ray, nasopharyngeal cancer.

INTRODUCTION The design and synthesis of coordination polymers (CPs) have received great interest due to wonderful structures and properties of various molecular building blocks connected by coordination bonds and supramolecular contacts and due to their potentially wide applications in functional materials [1-4]. A great many of CPs have been documented, such as onedimensional (1D) chains and ladders, two-dimensional (2D) grids, three-dimensional (3D) microporous networks, interpenetrated modes, and helical staircase networks [5-8]. Among these, particular attention has been recently devoted to systems containing entanglements of individual motifs. Nevertheless, it is still a great challenge to rationally design and construct the desired compounds. The structures of CPs built by coordination bonds and/or supramolecular contacts can be dramatically changed by minor tuning factors. Many factors, such as organic ligands, solvent systems, metal ions, and counterions, are found to greatly influence the structures, rendering it difficult to predict the construction of molecular architectures [9-17]. Of all these, the choice of ligands is a key factor. Donor atoms, functional groups, and relative positions can directly vary framework structures. Moreover, flexible ligands also have attracted special interest because their flexible conformations are expected to produce many intriguing architectures such as polymorphic, entangled, and so on. Therefore,

1

Otolaryngology and Maxillofacial Surgery, People′s Hospital of Wuwei City, Wuwei, Gansu, People′s Republic of China. Integrated TCM and Western Medicine Department, People′s Hospital of Wuwei City, Wuwei, Gansu, People′s Republic of China. 3E.N.T. Department, People′s Hospital of Wuwei City, Wuwei, Gansu, People′s Republic of China; *[email protected]. Original article submitted February 20, 2020; revised April 2, 2020; accepted April 9, 2020. 2

1468

0022-4