TWO NEW Co(II)-BASED COORDINATION POLYMERS: CRYSTAL STRUCTURES AND THE LOCAL ANALGESIA ACTIVITY DUE TO REDUCING LOCAL AC

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TWO NEW Co(II)-BASED COORDINATION POLYMERS: CRYSTAL STRUCTURES AND THE LOCAL ANALGESIA ACTIVITY DUE TO REDUCING LOCAL ACETYLCHOLINE CONTENTS Z.-Y. Liu1 and Y.-Y. Li1*

Two new Co(II)-based coordination polymers {[Co(L)](DMF)}n (1, H2L = 5-(1H-imidazol-1-yl)isophthalic acid) and {[Co2(L)2(H2O)]⋅3H2O}n (2) are successfully synthesized by the hydrothermal or solvothermal method. The resulting single crystal X-ray diffraction studies demonstrate that complex 1 presents a 3D 3,6-connected framework with a binuclear Co(II) paddle-wheel cluster as the secondary building unit, while complex 2 displays a 3,3,4,8-connected 3D network structure with the a trinuclear linear Co3(CO2)6 cluster as the secondary building unit. The in vivo local anesthesia activity of compounds 1 and 2 is evaluated via the mice hot plate analgesic experiment. Then, the local content of acetylcholine in mice is measured by the ELISA assay. DOI: 10.1134/S002247662008017X Keywords: coordination polymer, mixed ligand, Co(II)-complex, local anesthesia activity.

INTRODUCTION Local anesthetics are the most commonly used drugs in clinical anesthesia and pain treatment. Although many scholars have performed many experimental researches on the dosage form, dosage and toxicity of local anesthetics, and proposed many clinically effective methods [1, 2], however, the adverse reactions caused by local anesthetics are still rising. The traditional analgesia exert activity via binding with the voltage-gated sodium (Nav) channels on the neuron membranes, which is reported to cause respiratory failure, seizures, palpitations, and irregular cardiac function in clinical treatment [3, 4]. Thus, in this research, we aimed at the design, synthesis, and evaluation of the activity of new compounds as candidates for local analgesia treatment. In recent years, coordination polymers (CPs) have been widely synthesized not only for gorgeous structures, but also for many their potential uses, such as gas storage, ion exchange, separation, catalysis, and so on [5-8]. However, it is still a challenge to predict and control the final architectures of the desired crystalline products due to the structural uncertainty and diversity since the network formation is sensitive to many factors such as organic ligands, metal ions, metal-to-ligand ratio, template, solvents, pH value, reaction temperature, the method of crystallization, etc. [9-12]. Among them, organic ligands and metal ions are the two major aspects that should be considered in the construction of CPs. As it is known,

1

Department of Anesthesiology, Second Hospital of Nantong, Nantong, Jiangsu, P. R. China; *[email protected] Original article submitted October 19, 2019; revised November 7, 2019; accepted November 11, 2019. 1306

0022-4766/20/6108-1306 © 2020 by Pleiades Publishing, Ltd.

multicarboxylate ligands, such as 1,4-benzenedicarboxylate, 1,3,5-benzenetribenzoate, 3,3′,5,5′-biphenyl tetracarboxylate, 1,1′-ethynebenzene-3,3′,5,5′-tetracarboxylate, 1,1′-butadiynebenzene-3,3′,5,5′-tetracarboxylate, have been wide