Two Transition Metal Coordination Polymers: Luminescent Sensing Properties and Treatment Effect on Chronic Periodontitis

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ORIGINAL ARTICLE

Two Transition Metal Coordination Polymers: Luminescent Sensing Properties and Treatment Effect on Chronic Periodontitis by Reducing IL-6 and TNF-α Content Lei Mi 1 & Xue Zhang 2 & Wenjing Hao 3 & Shuai Wang 3 Received: 3 August 2020 / Accepted: 9 November 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020

Abstract Two novel sulfonic functionalized coordination polymers (CPs) {[Cd1.5(dimb)(5-sip)(H2O)3]·3H2O}n (1, dimb = 1,4-di(1Himidazol-1-yl)butane) and [Co2(iptz)(Hiptz)(5-sip)(H2O)]·4H2O (2, Hiptz = 1-(4-(1H-imidazole-5-yl)phenyl)-1H-1,2,4-triazole) were acquired via different metal(II) salts reacting with the mixed ligands containing 1-(4-(1H-imidazole-5-yl)phenyl)-1H-1,2,4triazole, 1,4-di(1H-imidazol-1-yl)butane and sodium 5-sulfoisophthalate (NaH2sip), respectively. Furthermore, the complex 1 based on Cd(II) could be utilized as the luminescent senor for picric acid (PA) detection in water. In bio-research, compounds 1 and 2 treatment effect on chronic periodontitis was assessed and the specific mechanism was discussed. First of all, the RT-PCR was performed to measure the HmuY and fimA genes relative expression level in P.gingivalis after treated by compounds 1 and 2. Then, the TNF-α and IL-6 content in the fluid of gingival crevicular after compounds treatment was determined with ELISA detection kit. Keywords Coordination polymer . Mixed-ligand . PA sensor . Chronic periodontitis

Introduction Periodontal disease is an infectious disease that occurs in dental support tissues, and plaque microorganisms are the main cause of occurrence of periodontal disease [1]. Many researches have confirmed that Porphyromonas gingivalis (P.gingivalis) is the most important pathogenic bacteria during occurrence of various periodontal diseases, especially chronic periodontitis [2]. P.gingivalis is a kind of Gramnegative bacteria closely associated with the development and occurrence for the periodontal disease and plays a very important role in it. Examination of oral plaque found that the

* Xue Zhang [email protected] 1

Department of Stomatology, Yulin First Hospital, Yulin, Shaanxi, China

2

Department of Stomatology, Tangshan Central Hospital, Tangshan, Hebei, China

3

Department of Chemistry, Qingdao Medical University, Qingdao, Shandong, China

detection rates of P.gingivalis, F. parasitei, and Treponema pallidum in patients with periodontitis were obviously higher than in healthy people, which are extremely relevant to human periodontal disease [3, 4]. In recent decades, coordination polymers (CPs) have attracted more and more attention due to their unique structural characteristics, at the same time owing to their applications in catalysis, luminescence, gas separation, adsorption, magnetism and other fields [5–9]. The main reasons for CPs design are chiefly concentrated upon the choice of organic ligands and metal ions as the spacers and nodes [10–12]. At the same time, the properties of metal ions have a great influence on the features of CPs. For instance, CPs compose