• PDF / 945,453 Bytes
• 7 Pages / 612 x 792 pts (letter) Page_size
• 70 Downloads / 179 Views

DOWNLOAD

REPORT

---

TWO NEW Co(II)-BASED COORDINATION POLYMERS: STRUCTURAL CHARACTERIZATION AND PROTECTIVE EFFECT ON PARKINSON DISEASE BY IMPROVING THE CONTENT OF DOPAMINE IN THE SUBSTANTIA NIGRA F.-L. Yue1, S.-B. Ma2, X. Wang1, X.-Q. Wen1, C.-N. Sang1, and C.-F. Cui1*

Two new mixed-ligand coordination polymers with the chemical formulae {[Co(5-amipa)(bpe)]DMF}n (1, H2amipa = 5-aminoisophthalic acid, bpe = 1,2-bis(4-pyridyl)ethylene, DMF = dimethylformamide) and {[Co(5-amipa)(bpe)](DMA)}n (2, DMA = dimethylacetamide) are successfully synthesized by the solvothermal reaction of 5-aminoisophthalic acid and the N-donor 1,2-bis((4-pyridyl)ethylene) co-ligand with Co(II) salt in different solvent systems. All compounds are adequately characterized, and their structures are verified by single crystal X-ray diffraction along with the elemental analysis. Furthermore, the protective effect of compounds 1 and 2 on Parkinson disease is evaluated in the biological function section. Firstly, the ELISA detection is performed to estimate the dopamine content in the substantia nigra after treatment with the compounds. Then the open field test is finished to reflect the treatment ability of the compounds on the cognitive ability of mice. DOI: 10.1134/S0022476620080132 Keywords: coordination polymer, mixed ligand, Co(II) complex, Parkinson disease, substantia nigra.

INTRODUCTION Parkinson disease is one of the most common neurodegenerative diseases, with the character of slowness and paucity of movement (bradykinesia), muscle rigidity, resting tremors, and disordered posture [1]. Within the 10th to 25th years of initial symptoms, the character of Parkinson patients will slow progress to akinesia, severe tremors, physical disability, and even death [2]. In the USA, there is approximately 1% of Americans affected with Parkinson disease above the age of 60 years. However, the detailed mechanism of Parkinson disease has been unknown, but the researchers have revealed that usually there was a loss of dopamine-containing neurons in the substantia nigra pars compacta of the brainstem and disruption of normal dopaminergic neurotransmission [3, 4]. Now, more and more researchers are interested in Parkinson disease treatment and improvement of the quality of life and survival [5]. The design and synthesis of coordination polymers (CPs) have attracted uprising research interest not only due to their structural and topological novelty but also owing to their tremendous potential applications in gas storage, chemical separations, ion exchange, microelectronics, nonlinear optics, and heterogeneous catalysis [6-10]. The careful selection

1

Department of Neurology, 521 Hospital of Norinco Group, Xi′an, P. R. China; *[email protected]. Department of Neurology, Dalian Municipal Central Hospital, Dalian, P. R. China. Original article submitted November 5, 2019; revised January 1, 2020; accepted January 27, 2020.

2

1274

0022-4766/20/6108-1274 © 2020 by Pleiades Publishing, Ltd.

of organic ligands and suitable metal ions are required to construct framework archi