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TWO Yb(III)-CONTAINING COORDINATION POLYMERS: STRUCTURAL INSIGHTS AND SYNERGY EFFECT WITH SEVENTY-FLAVOR PEARL PILLS ON CEREBRAL ISCHEMIA BY REGULATING MONOAMINE NEUROTRANSMITTERS H. Ma1, H. Rong1, J.-J. Zhang1, J.-M. Shi1, and Z.-Q. Sun1*

In this work, we report the synthesis of two new Yb(III)-based coordination polymers [Yb(Btca)(Idc)(H2O)]n (1, HBtca = 1H-benzo[d][1,2,3]triazole-5-carboxylic acid and H3Idc = 1H-imidazole-4,5-dicarboxylic acid) and [Yb2(Thz)3⋅8H2O)]⋅H2O (2, H2Thz = thiazolo[5,4-d]thiazole-2,5-dicarboxylic acid) prepared under the solvothermal conditions using two heterodonor organic ligands. The two complexes are fully determined via single crystal X-ray diffraction along with the elemental analysis. Furthermore, the synergy effect of compounds 1 and 2 with seventy-flavor pearl pills on the cerebral ischemic events is evaluated in vivo. Firstly, the enzyme-linked immunosorbent assay (ELISA) is performed to measure the content of dopamine and 5-serotonin in the brain after treatment with compounds 1 and 2. Then, the reactive oxygen species (ROS) detection is conducted to determine the inhibitory effect of the compounds on the inflammatory level in the brain. DOI: 10.1134/S0022476620080156 Keywords: coordination polymer, Yb(III) complex, single crystal X-ray diffraction, seventy-flavor pearl pills.

INTRODUCTION Stroke is the third most deadly disease after heart disease and cancer. Annual health care costs in the United States are as high as $62 billion [1]. Currently, stroke treatments is imitated, and the only FDA-approved stroke treatment is the tissue plasminogen activator used to reopen blocked blood vessels [2]. However, due to the narrow treatment window, this treatment is suitable only for a small number of patients. Therefore, it is imperative to find new therapies for clinic treatment [3]. Both dopamine and 5-serotonin belong to monoamine neurotransmitters. Many studies have shown that the metabolism of extracellular monoamine neurotransmitters is disordered during cerebral ischemia, and the vital role of monoamine neurotransmitters in ischemic brain injury has received much attention of the researchers [4]. Dopamine is mainly distributed in the nigra-striatum system in the brain. Previous studies have shown that the destruction of the substantia nigra causes dopamine depletion in the striatum, which protects striatal neurons from ischemic cell death [5].

1

School of Medicine, Xizang Minzu University, Xianyang, P. R. China; *[email protected]. Original article submitted November 14, 2019; revised January 1, 2020; accepted January 9, 2020. 1288

0022-4766/20/6108-1288 © 2020 by Pleiades Publishing, Ltd.

Coordination polymers (CPs) have attracted attention due to the structural versatility toward combining the properties of organic ligands and metal ions. A variety of structures with different dimensionalities (from 1D to 3D) and the molecular arrangement are possible for these materials [6-8]. Several CPs with properties and applications such as magnetism, luminescence, catalysis,