Malaria Vaccines Methods and Protocols
This volume focuses on malaria vaccinology, and introduces researchers to a complete overview of the protocols and tools used by molecular and cellular malariologists. The chapters within this book talk about interventions concerning all aspects of life c
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Ashley M. Vaughan Editor
Malaria Vaccines Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Malaria Vaccines Methods and Protocols
Edited by
Ashley M. Vaughan Center for Infectious Disease Research, Seattle, WA, USA
Editor Ashley M. Vaughan Center for Infectious Disease Research Seattle, WA, USA
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-2814-9 ISBN 978-1-4939-2815-6 (eBook) DOI 10.1007/978-1-4939-2815-6 Library of Congress Control Number: 2015945589 Springer New York Heidelberg Dordrecht London © Springer Science+Business Media New York 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Humana Press is a brand of Springer Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)
Preface The most effective way to control and ultimately eliminate an infectious disease is through vaccination. Man has successfully eliminated small pox with this ingenious strategy but other diseases are proving harder to eradicate, even when highly effective vaccines do exist. Malaria is caused by the eukaryotic pathogen parasite Plasmodium, and to date no efficacious vaccine against any eukaryotic pathogen is widely available. Nevertheless seminal studies in the 1960s showed the power of immunity in controlling malaria disease. In 1961 Sydney Cohen and colleagues showed that the passive transfer of gamma immunoglobulin from adults living in areas of high malaria endemicity to young children with severe malaria disease could help eliminate parasites from the blood. This study clearly demonstrated the ability of humoral immunity to control severe disease. In 1967, Ruth Nussensweig and colleagues demonstrated that the immunization of mice with irradiated Plasmodium berghei sp
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