Valproic acid
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Fatal acute liver failure in a child with AlpersHuttenlocher syndrome: case report A 3-year-old boy with developmental delay and ataxia began receiving valproic acid [route and dosage not stated] for seizures. After 2 months, he developed acute liver failure. Investigations led to a diagnosis of AlpersHuttenlocher syndrome. He developed progressive neurological impairment and died within 2 days. He was found to have a novel POLG mutation. Author comment: "Our patient showed a severe clinical phenotype and died due to valproate induced fatal acute liver failure. . . The presented study extends the list of POLG mutations associated with [valproic acid] hepatotoxicity." Schaller A, et al. Molecular and biochemical characterisation of a novel mutation in POLG associated with Alpers syndrome. BMC Neurology 11: No. 4, 14 Jan 2011. Available from: URL: http://dx.doi.org/10.1186/1471-2377-11-4 803050804 Switzerland
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Reactions 12 Mar 2011 No. 1342
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