Valproic acid
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Valproic acid Hair disorders and various toxicities in a child: case report A 7-year-old boy developed hair disorders during treatment with valproic acid; he also experienced minor changes in his coagulation parameters, dysgeusia, dysosmia, loss of appetite and occasional vomiting. The boy, who had developed herpes encephalitis at the age of 9 months, experienced mild spastic hemiparesis and complex partial seizures involving his right leg and arm, with and without impaired consciousness. He initially received phenytoin, phenobarbital and carbamazepine without success. He started receiving valproic acid with a blood concentration of 135 mg/L [dosage not stated]. Sultiame was added and he experienced complete control of his seizures. Five months after valproic acid initiation, hair loss was observed. His hair colour changed from brown to ash blond and his hair became scrubby, dry and lusterless. He also experienced minor changes to his coagulation parameters, dysgeusia, dysosmia, loss of appetite and occasional vomiting [time to reaction onset not stated]. Valproic acid was discontinued and, 5 months later, his hair loss stopped and his hair colour changed back to brown; his hair also became smooth. His dysgeusia and dysosmia resolved and his coagulation parameters normalised. Gerstner T, et al. Valproate-induced change in hair colour. Journal of the American Academy of Dermatology 58 (Suppl. 1): 63-64, No. 2, Feb 2008 801079762 Germany
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Reactions 9 Feb 2008 No. 1188
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