Varicella zoster virus vaccine live
- PDF / 141,637 Bytes
- 1 Pages / 623.591 x 841.847 pts Page_size
- 58 Downloads / 183 Views
1
Varicella zoster virus vaccine live Varicella zoster virus infections with secondary transmission: case report A 16-year-old boy in a chronic care facility developed severe varicella zoster virus infection after receiving varicella zoster virus vaccine live [Varivax]. Secondary transmission of at least two variant vaccine strains subsequently occurred in two other residents at the same chronic care facility. The boy had multiple medical problems, but was immunocompetent and had no previous history of chickenpox. He was given a single SC dose of varicella zoster virus vaccine live 0.5mL. Fifteen days later, he developed fever and a chickenpox-like skin eruption. Within 4 days, he had over 500 vesicles on his body. His fever persisted for 8 days and crusting of his skin lesions occurred 11 days after onset of the skin eruption. The boy was treated empirically with clindamycin and ceftriaxone and recovered without complications. Analysis of a vesicular lesion revealed the presence of Oka-strain varicella zoster virus. Secondary transmission of varicella zoster virus vaccine strains occurred in a 12-year-old girl and a 39-year-old woman, with fever and a mild vesicular skin eruption occurring 19–21 days after the onset of skin eruption in the 16-year-old boy. Both of these patients were immunocompetent and both had a previous history of chickenpox. Neither patient had been in direct contact with the 16-year-old boy, but they had the same caregivers. Material from vesicular lesions was Okastrain positive for varicella zoster virus in both patients. Author comment: "On admission to chronic care facilities, children should be assessed for evidence of immunity to varicella and vaccinated if considered susceptible. If doubt exists about the reliability of history of previous infection with varicella, then serologic testing is appropriate." Grossberg R, et al. Secondary transmission of varicella vaccine virus in a chronic care facility for children. Journal of Pediatrics 148: 842-844, No. 6, Jun 2006 801043029 USA
0114-9954/10/1115-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 19 Aug 2006 No. 1115
Data Loading...
