X-Ray Contrast Media OVERVIEW, USE AND PHARMACEUTICAL ASPECTS

This open access book is an overview on CT/X-ray contrast media designed for radiologists and other medical specialists who use contrast media in imaging and interventional procedures as well as related scientists on the use and pharmaceutical aspect

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X-Ray Contrast Media Overview, Use and Pharmaceutical Aspects 5. Auflage

X-Ray Contrast Media

Ulrich Speck

X-Ray Contrast Media Overview, Use and Pharmaceutical Aspects 5. Auflage

Ulrich Speck InnoRa GmbH Berlin, Germany

ISBN 978-3-662-56464-6 ISBN 978-3-662-56465-3  (eBook) https://doi.org/10.1007/978-3-662-56465-3 Library of Congress Control Number: 2018934958 © The Editor(s) (if applicable) and The Author(s) 1991, 1993, 1994, 1999, 2018. This book is an open access publication. Open Access This book is licensed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made. The images or other third party material in this book are included in the book’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the book’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Open Access is sponsored by Bayer AG, Berlin Fotonachweis Umschlag: (c) BBMG GmbH//Umschlaggestaltung: deblik Berlin Printed on acid-free paper This Springer imprint is published by the registered company Springer-Verlag GmbH, DE part of Springer Nature The registered company address is: Heidelberger Platz 3, 14197 Berlin, Germany

CONTENT

INTRODUCTION

10

Historical Aspects

10

Contrast media in X-ray imaging

13

Visualization of functions

13

Morphology

13

GENERAL PRINCIPLES OF X-RAY CONTRAST MEDIA

16

Physical Principles

18

STRUCTURE AND PROPERTIES OF X-RAY CONTRAST MEDIA

20

Barium Sulfate

20

Lipiodol

21

Water-soluble contrast media

24

Chemical structure, biological behavior and use

24

High-osmolar, ionic contrast media

25

Low-osmolar substances

26

Nonionic contrast media

26

Osmolality and side effects caused by hypertonicity

28

Ionic contrast media

30

Contrast media for intravenous cholegraphy

31

Cations

31

Synthesis of