Yeast Genetic Networks Methods and Protocols
Regulation of gene expression, a major determinant of gene activity, occupies a central place in molecular biology. Yeast Genetic Networks: Methods and Protocols covers approaches to the systems biological analysis of small-scale gene networks in yeast. D
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MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
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Yeast Genetic Networks Methods and Protocols
Edited by
Attila Becskei Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland
Editor Attila Becskei Institute of Molecular Life Sciences University of Zurich Zurich Switzerland [email protected]
ISSN 1064-3745 e-ISSN 1940-6029 ISBN 978-1-61779-085-0 e-ISBN 978-1-61779-086-7 DOI 10.1007/978-1-61779-086-7 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011923964 ª Springer ScienceþBusiness Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer ScienceþBusiness Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana press is a part of Springer Science+Business Media (www.springer.com)
Preface A gene changes the activity of the genes it interacts with. The entirety of these effects in a set of genes represents the dynamical behavior of a gene network. The analysis of this behavior can reveal how a network stabilizes the expression level of its components against perturbations, how it specifies the range of signaling intensity and frequency that can be efficiently transmitted in a pathway, or how it induces gene expression to oscillate. Regulation of gene expression a major determinant of gene activity occupies a central place in molecular biology. A detailed mechanistic description of the processes involved, methods for highly quantitative measurements, and an array of biotechnological tools are available to understand, to measure and to control gene expression. These favorable conditions explain why yeast genetic networks attracted the attention of many scientists in the nascent field of molecular systems biology. The book Yeast Genetic Networks: Methods and Protocols covers approaches to the systems biological analysis of small-scale gene networks in yeast. Gene expression is primarily d
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