Antimicrobial and antileishmanial activities of extracts and some constituents from the leaves of Solanum chrysotrichum
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Medicinal Chemistry Research https://doi.org/10.1007/s00044-020-02648-8
ORIGINAL RESEARCH
Antimicrobial and antileishmanial activities of extracts and some constituents from the leaves of Solanum chrysotrichum Schldl Guillermo Núñez-Mojica1 Verónica M. Rivas-Galindo2 Elvira Garza-González3 Luis D. Miranda4 Adriana Romo-Pérez4 Fabrice Pagniez5 Carine Picot5 Patrice Le Pape5 Marc-Antoine Bazin5 Pascal Marchand5 María del Rayo Camacho-Corona 1 ●
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Received: 3 August 2020 / Accepted: 6 October 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Three organic extracts were prepared from the leaves of Solanum chrysotrichum Schldl. From the methanol extract were isolated two new steroidal saponins (1, 2), and three known compounds (3, 4, and 5). The new saponins were elucidated as 6-α-O-α-Lrhamnopyranosyl-(1 → 3)-β-D-quinovopyranosyl-(25S)-5α-spirostan-3β-ol (1) and 6-α-O-α-L-rhamnopyranosyl-(1 → 3)-β-Dquinovopyranosyl-(23R,25S)-5α-spirostan-3β,23β-ol (2). The structural elucidation of compounds was performed by analysis of 1D and 2D NMR spectral data and HRMS. Antibacterial activity was displayed by the hexane and CH2Cl2 extracts against carbapenem-resistant Pseudomonas aeruginosa (MIC = 250 μg/mL) and carbapenem-resistant Acinetobacter baumannii (MIC = 125 μg/mL). The known saponin (3) was the only compound active against bacteria, showing activity against all the gram-positive bacteria (MIC = 12.5 μg/mL). Antitubercular activity was observed only for the hexane extract (MIC = 250 μg/mL). The antifungal and antileishmanial activities were determined for the steroidal saponins, but they were devoid of antifungal activity at the concentrations tested. Antileishmanial activity was shown only by the saponin (1) (IC50: 21.64 ± 1.21 μg/mL). Graphical Abstract
Keywords Solanum chrysotrichum Schldl Solanaceae Steroidal saponins Antimicrobial Antileishmanial ●
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Supplementary information The online version of this article (https:// doi.org/10.1007/s00044-020-02648-8) contains supplementary material, which is available to authorized users. * Pascal Marchand [email protected]
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Servicio de Gastroenterología Hospital Universitario Dr. José Eleuterio González, Universidad Autonoma de Nuevo Leon, Av. Gonzalitos y Madero S/N, Col. Mitras Centro, CP, 64460 Monterrey, Nuevo León, México
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Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior s/n, Ciudad universitaria, C.P., 04510 Coyoacán, Ciudad de México, México
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Cibles et Médicaments des Infections et du Cancer, Université de Nantes, IICiMed, EA 1155, F-44000 Nantes, France
* María del Rayo Camacho-Corona [email protected] 1
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Facultad de Ciencias Químicas, Universidad Autonoma de Nuevo Leon, Av. Universidad S/N, Ciudad Universitaria, CP, 66451 San Nicolás de los Garza, Nuevo León, México Facultad de Medicina, Universidad Autonoma de Nuevo Leon, Av. Madero S/N, Col. Mitras Centro, CP, 64460 Monterrey, Nuevo León, México
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