Hypertension Methods and Protocols
This volume provides comprehensive protocols that researchers can use to dissect out fundamental principles and molecular mechanisms of hypertension, extending from genetics of experimental hypertension to biomarkers in clinical hypertension. Hypertension
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Rhian M. Touyz Ernesto L. Schiffrin Editors
Hypertension Methods and Protocols
Methods
in
Molecular Biology
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Hypertension Methods and Protocols
Edited by
Rhian M. Touyz Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom
Ernesto L. Schiffrin Lady Davis Institute for Medical Research and Department of Medicine, Jewish General Hospital, McGill University, Montreal, QC, Canada
Editors Rhian M. Touyz Institute of Cardiovascular and Medical Sciences University of Glasgow Glasgow, Scotland United Kingdom
Ernesto L. Schiffrin Lady Davis Institute for Medical Research and Department of Medicine Jewish General Hospital McGill University Montreal, QC, Canada
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-6623-3 ISBN 978-1-4939-6625-7 (eBook) DOI 10.1007/978-1-4939-6625-7 Library of Congress Control Number: 2016956249 © Springer Science+Business Media LLC 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Despite the availability of a plethora of very effective antihypertensive drugs, the treatment of hypertension remains suboptimal and the prevalence of hypertension is increasing, contributing to the major cause of morbidity and mortality worldwide. Reasons for this relate, in part, to a lack of understanding of the exact mechanisms underlying the pathogenesis of hypertension, which is complex involving interactions between genes, physiological processes, and environmental factors. To gain insights into this complexity, studies at the molecular, s
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