Bacterial Protein Secretion Systems Methods and Protocols
This volume details protocols that cover the broad arsenal of techniques used to study a secretion system from A to Z. Chapters focus on identifying and localizing the different subunits, defining interactions within subunits, monitoring conformation
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Laure Journet Eric Cascales Editors
Bacterial Protein Secretion Systems Methods and Protocols
Methods
in
Molecular Biology
Series editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Bacterial Protein Secretion Systems Methods and Protocols Editors
Laure Journet and Eric Cascales Institut de Microbiologie de la Méditerranée, Aix-Marseille Univ - CNRS, Marseille, France
Editors Laure Journet Institut de Microbiologie de la Méditerranée Aix-Marseille Univ - CNRS Marseille, France
Eric Cascales Institut de Microbiologie de la Méditerranée Aix-Marseille Univ - CNRS Marseille, France
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-7031-5 ISBN 978-1-4939-7033-9 (eBook) DOI 10.1007/978-1-4939-7033-9 Library of Congress Control Number: 2017944103 © Springer Science+Business Media LLC 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface In their ecological niches, bacteria are in contact with other prokaryotic and eukaryotic cells. Bacteria therefore evolved mechanisms to communicate and collaborate with these cells. They also developed belligerent behaviours to eliminate competitors and to infect eukaryotic host cells. These aggressive actions are mediated by effector toxins with specific activities which will ultimately cause target cell lysis or re-routing of metabolic or trafficking pathways in the host. The proper delivery of bacterial effectors into the milieu or directly into target cells is assured by dedicated structures called secretion sys
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