Unconventional Protein Secretion Methods and Protocols
This volume presents relevant background information to understanding the molecular basis governing unconventional protein secretion (UPS), and in particular explores the latest techniques and protocols that have been successfully applied for the study of
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Andrea Pompa Francesca De Marchis Editors
Unconventional Protein Secretion Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Unconventional Protein Secretion Methods and Protocols
Edited by
Andrea Pompa and Francesca De Marchis Instituto di Bioscienze e Biorisorse, Perugia, Italy
Editors Andrea Pompa Instituto di Bioscienze e Biorisorse Perugia, Italy
Francesca De Marchis Instituto di Bioscienze e Biorisorse Perugia, Italy
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-3802-5 ISBN 978-1-4939-3804-9 (eBook) DOI 10.1007/978-1-4939-3804-9 Library of Congress Control Number: 2016947706 © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC New York
Preface The envious billows sidelong swell to whelm my track; let them; but first I pass (Captain Ahab; Moby Dick)
The essential function of the secretory proteins is to sense the environment and to drive the correct development of monocellular and, especially, pluricellular organisms. These polypeptides mediate fundamental processes in all the living organisms, such as cell-to-cell communication, defense response, and many others. Protein secretion is essentially achieved by two mechanisms. In the classic secretory pathway, proteins travel from the endoplasmic reticulum (ER), where they are inserted thanks to an amino acidic N-terminal signal peptide (SP) sequence, through the Golgi apparatus and finally reach the extracellular space or the lysosome/vacuole. Alongside this well-characterized route, an unconventional protein secretion (UPS) has been described which incorporates all the mechanisms that do no
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