Bacterial Persistence Methods and Protocols
This volume presents a comprehensive collection of methods that have been instrumental to the current understanding of bacterial persisters. Chapters in the book cover topics ranging from general methods for measuring persister levels in Escherichia coli
- PDF / 6,305,921 Bytes
- 241 Pages / 504.63 x 737.01 pts Page_size
- 107 Downloads / 207 Views
Jan Michiels Maarten Fauvart Editors
Bacterial Persistence Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, UK
For further volumes: http://www.springer.com/series/7651
Bacterial Persistence Methods and Protocols
Edited by
Jan Michiels and Maarten Fauvart Department of Microbial and Molecular Systems, KU Leuven - University of Leuven, Heverlee, Belgium
Editors Jan Michiels Department of Microbial and Molecular Systems KU Leuven - University of Leuven Heverlee, Belgium
Maarten Fauvart Department of Microbial and Molecular Systems KU Leuven - University of Leuven Heverlee, Belgium
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-2853-8 ISBN 978-1-4939-2854-5 (eBook) DOI 10.1007/978-1-4939-2854-5 Library of Congress Control Number: 2015945939 Springer New York Heidelberg Dordrecht London # Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Humana Press is a brand of Springer Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)
Preface Antibiotic treatment often fails to clear chronic infections, even in the absence of clinically detectable resistance. This is largely due to the so-called persister cells that can survive exposure to high concentrations of bactericidal antibiotics. It is generally accepted that persisters are responsible for the relapse of infections by notorious pathogens such as Mycobacterium tuberculosis, Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella Typhimurium, and Candida albicans. Persisters typically make up only a small part of a cell population. They result from a temporary switch to a state that is insensitive to killing by antibiotics. Their rare and transient nature has long hampered the experimental study of persisters. This volume brings toget
Data Loading...
