Bone Morphogenetic Proteins: Systems Biology Regulators
This book focuses on the salient features of the biology of Bone Morphogenetic Proteins and the advances in our understanding of their structure and function and of downstream signaling, as well as their governance in systems biology from bone and dentin
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Slobodan Vukicevic Kuber T. Sampath Editors
Bone Morphogenetic Proteins: Systems Biology Regulators
Progress in Inflammation Research Series Editors Michael J. Parnham Fraunhofer IME & Goethe University Frankfurt, Germany Achim Schmidtko Goethe University Frankfurt, Germany
More information about this series at http://www.springer.com/series/4983
Slobodan Vukicevic • Kuber T. Sampath Editors
Bone Morphogenetic Proteins: Systems Biology Regulators
Editors Slobodan Vukicevic School of Medicine University of Zagreb Zagreb Croatia
Kuber T. Sampath perForm Biologics Inc Holliston Massachusetts USA
Series Editors Michael J. Parnham Fraunhofer IME & Goethe University Frankfurt Germany
Achim Schmidtko Goethe University Frankfurt Germany
Progress in Inflammation Research ISBN 978-3-319-47505-9 ISBN 978-3-319-47507-3 (eBook) DOI 10.1007/978-3-319-47507-3 Library of Congress Control Number: 2016963598 © Springer International Publishing AG 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
In mid-1960, Marshall Urist described the phenomenon that demineralized bone matrix (DBM) contained “bone morphogenetic protein, BMP,” which has the ability to induce new bone in vivo. As the formation of new bone involves a cascade of cellular events such as cell migration, proliferation, and differentiation into endochondral bone, mimicking embryonic bone development, it was long believed that more than one protein was involved. In early 1980, the discovery that the proteins responsible for bone induction in DBM could be extracted and reconstituted with collagenous bone matrix and assayed for in vivo bone forming activity at ectopic sites has made possible the identification of BMP by employing protein purification and molecular cloning. A single reco
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