Prostate Cancer Methods and Protocols
This volume presents methods and protocols on modern analysis of steroid receptor and prostate cancer function. Chapters detail androgen, androgen receptor action, anti-androgen enzalutamide, in vitro and in vivo models, imaging, gene fusions, and help fa
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Zoran Culig Editor
Prostate Cancer Methods and Protocols
Methods
in
M o l e c u l a r B i o lo g y
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Prostate Cancer Methods and Protocols
Edited by
Zoran Culig Department of Urology, Innsbruch Medical University, Innsbruck, Austria
Editor Zoran Culig Department of Urology Innsbruch Medical University Innsbruck, Austria
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-7843-4 ISBN 978-1-4939-7845-8 (eBook) https://doi.org/10.1007/978-1-4939-7845-8 Library of Congress Control Number: 2018942021 © Springer Science+Business Media, LLC, part of Springer Nature 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by the registered company Springer Science+Business Media, LLC part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Progress has been made in the development of cellular and animal models for prostate cancer. In addition to cell lines which have been used over many years in research, patient-derived xenograft models are available for studying specific questions in prostate cancer biology. Combination of various cellular and animal models is reasonable especially in research with novel drug substances for targeting oncogenes in prostate cancer. Experimental procedures in order to develop novel models are the focus of this chapter. Our authors also provided contributions on imaging, an area in which rapid progress is observable. Methodologies described in this book will allow readers to learn about modern analysis of steroid receptor function. Androgen receptor is a recognized target in ca
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