Cellular Programming and Reprogramming Methods and Protocols
Before the therapeutic potential of cell replacement therapy or the development of therapeutic drugs for stimulating the body’s own regenerative ability to repair cells damaged by disease and injury can be fully realized, control of stem cell fate, immuno
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Molecular Biology™
Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
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Cellular Programming and Reprogramming Methods and Protocols
Edited by
Sheng Ding Ph.D. Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA
Editor Sheng Ding, Ph.D. Department of Chemistry The Scripps Research Institute La Jolla, CA USA [email protected]
ISSN 1064-3745 e-ISSN 1940-6029 ISBN 978-1-60761-690-0 e-ISBN 978-1-60761-691-7 DOI 10.1007/978-1-60761-691-7 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010922991 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is a part of Springer Science+Business Media (www.springer.com)
Preface Advances in stem cell biology are making possible new approaches to treat devastating human diseases, including cardiovascular disease, neurodegenerative disease, musculoskeletal disease, diabetes, and cancer. Such approaches may involve cell replacement therapy as well as the development of therapeutic drugs for stimulating the body’s own regenerative ability to repair cells damaged by disease and injury. However, obstacles such as control of stem cell fate, immunorejection, and limited cell sources must be overcome before their therapeutic potentials can be realized. Recent studies have suggested that tissuespecific cells may overcome their intrinsic lineage-restriction to dedifferentiate or transdifferentiate upon exposure to a specific set of signals in vitro and in vivo. The ability to dedifferentiate or reverse lineage-committed cells to pluripotent/multipotent cells might overcome many of the obstacles (e.g., cell sources, immunocompatibility, and bioethical concerns) associated with using ES and adult stem cells in clinical applications. With an efficient dedifferentiation
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