Natural Killer Cell Protocols Cellular and Molecular Methods
As the research has continued, it has become increasingly clear that natural killer (NK) cells are critical sentinels of the innate immune response, playing important roles in protecting the body from numerous pathogens and cancer in addition to contribut
- PDF / 8,052,838 Bytes
- 545 Pages / 569.697 x 825.019 pts Page_size
- 7 Downloads / 197 Views
Natural Killer Cell Protocols Cellular and Molecular Methods Second Edition
Edited by
Kerry S. Campbell
ME T H O D S
IN
MO L E C U L A R BI O L O G Y
Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For other titles published in this series, go to www.springer.com/series/7651
TM
Natural Killer Cell Protocols Cellular and Molecular Methods Second Edition
Edited by
Kerry S. Campbell Fox Chase Cancer Center, Philadelphia, PA, USA
Editor Kerry S. Campbell Fox Chase Cancer Center Institute for Cancer Research 333 Cottman Avenue Philadelphia PA 19111-2497 USA [email protected]
ISSN 1064-3745 e-ISSN 1940-6029 ISBN 978-1-60761-361-9 e-ISBN 978-1-60761-362-6 DOI 10.1007/978-1-60761-362-6 Library of Congress Control Number: 2009939929 © Humana Press, a part of Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper springer.com
Preface It is becoming increasingly clear that natural killer (NK) cells are critical sentinels of the innate immune response. NK cells play important roles in protecting the body from numerous pathogens and cancer in addition to contributing to normal pregnancy and impacting the outcomes of transplantation. They have the unique capacity to detect and immediately respond to abnormal cells in the body without prior exposure. NK cell responses include the classical tumor cytolytic activity for which they were named and for the production of a number of cytokines that directly contribute to or potentiate the immune response. Although efficient tolerance mechanisms appear to prevent NK cells from causing autoimmune diseases, a great deal of genetic evidence suggests that match or mismatch of certain NK cell regulatory receptors [namely killer cell Ig-like receptors (KIR)] and their MHC class I ligands can influence a wide variety of human pathological conditions, including altering outcomes of viral infections, transplantati
Data Loading...