Cellular Quiescence Methods and Protocols
This detailed volume explores methods and protocols that aim to increase our understanding of how cells enter a quiescent state during homeostasis and how cells exit quiescence and re-enter differentiating cell divisions to restore damaged tissues, essent
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H. Daniel Lacorazza Editor
Cellular Quiescence Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Cellular Quiescence Methods and Protocols Edited by
H. Daniel Lacorazza Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA
Editor H. Daniel Lacorazza Texas Children’s Hospital Baylor College of Medicine Houston, TX, USA
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-7370-5 ISBN 978-1-4939-7371-2 (eBook) DOI 10.1007/978-1-4939-7371-2 Library of Congress Control Number: 2017954401 © Springer Science+Business Media LLC 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Quiescence is defined as a state of quietness or inactivity. The concept of cellular quiescence has rapidly evolved in recent years from a default state devoid of extracellular nutrients to an actively regulated and reversible cell cycle arrest poised to re-enter the cell cycle in response to a combination of cell-intrinsic and cell-extrinsic factors. Recent technological breakthroughs have allowed the study of the regulation of cellular quiescence in well-defined stem cell subsets by either flow cytometric or tissue detection. A state of dormancy and inertness has clear implications in the maintenance of tissuespecific stem cells because this state is believed to preserve stemness and prevent the accumulation of genomic aberrations ensuring the regeneration of a healthy tissue during homeostasis or in respon
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