Ciprofloxacin
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Stevens-Johnson syndrome: case report A 28-year-old woman, with no allergic or medical history, began receiving ciprofloxacin 750mg twice daily [route not stated] for acute pyelonephritis on 8 September 2011. Twelve days after starting the drug, she developed erosions on her nasal, buccal and genital mucous membranes, conjunctival hyperaemia and numerous pruritic erythematous maculopapules with central haemorrhagic and necrotic features over her face, arms and trunk. Nicholsky’s sign was negative. Ciprofloxacin was withdrawn and she began receiving a corticosteroid. She recovered 15 days later and had no sequelae. Author comment: "The responsibility of ciprofloxacin was retained in front of a suggestive delay of occurrence (12 days) and a favourable evolution after drug [withdrawal]." Atheymen R, et al. Stevens-Johnson syndrome associated with ciprofloxacin. Fundamental and Clinical Pharmacology 26 (Spec. issue): 112 abstr. P454, Apr 803078782 2012. - Tunisia
0114-9954/10/1424-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 20 Oct 2012 No. 1424
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