Ciprofloxacin
- PDF / 170,825 Bytes
- 1 Pages / 595.245 x 841.846 pts (A4) Page_size
- 46 Downloads / 219 Views
1 S
Bullous type fixed drug eruption: case report A 49-year-old man developed bullous type fixed drug eruption during treatment with ciprofloxacin for diarrhoea associated with stomach pain [dosage not stated]. The man was hospitalised on 25 February 2020 with complaints of painful lesions on the thighs, finger gaps, legs, face and genital, which he had been experiencing since last 3 days. Anamnesis revealed that he had diarrhoea associated with stomach pain. Therefore, he had consulted a private practitioner on 20 February 2020 and had been prescribed oral ciprofloxacin tablet, rabeprazole, mefenamic acid, tinidazole and domperidone. Following administration of these medications, his diarrhoea had resolved. However, he had started experiencing difficulty in swallowing and pain in the mouth, followed by a sudden and high-grade fever associated with chills and rigors. Therefore, he had consulted another private practitioner and had been treated with amikacin, paracetamol and cetirizine. Thereafter, his fever had subsided. However, he had developed lesions on lips and genital parts of the body, which were reddish in colour and associated with pain, followed by fluid-filled lesions on the right thigh, bilateral upper limbs, left finger cleft and on the left foot which ruptured spontaneously to leave behind the hyperpigmented plaque. Upon current presentation, a thorough review of his medical history and past medications was performed which revealed a one year old history of ciprofloxacin-induced fixed drug eruption on 18 February 2019. Subsequent skin examination revealed hyperpigmented plaque with few bullae, which were present on the right and lower arms measuring 2 × 2cm on the left arm 4th digital cleft, on the right upper thigh measuring 3 × 4cm size and on the right and left foot measuring 4 × 4cm. Erythomatous erosions were noted on oral mucosa, hard plate, lips and the glance penis. Subungual hyperkeratosis was noted on the toenails with longitudinal ridges. He was diagnosed with bullous type fixed drug eruption due to ciprofloxacin. Upon analysis, the reaction was considered as Bizarre type (Type-B) of ADR with a moderate severity of level 4(a). Ciprofloxacin was discontinued. The man was treated with Ringer’s lactate solution, glucose, sodium chloride, ceftriaxone, pantoprazole, dexamethasone, paracetamol, silver sulfadiazine, ondansetron, glycerol andprednisolone. Following five days of hospital stay, he was discharged. There was significant improvement in his clinical symptoms and lesion appearance. Rawal KB, et al. Bullous type fixed drug eruption due to ciprofloxacin: A rare adverse drug reaction. International Journal of Pharmaceutical Research 12 (Suppl. 1): 456-459, 803499248 2020. Available from: URL: http://doi.org/10.31838/ijpr/2020.SP1.061
0114-9954/20/1820-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved
Reactions 5 Sep 2020 No. 1820
Data Loading...
