Colorimetric captopril assay based on oxidative etching-directed morphology control of silver nanoprisms
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ORIGINAL PAPER
Colorimetric captopril assay based on oxidative etching-directed morphology control of silver nanoprisms Pu Zhang 1 & Li Wang 2 & Jing Zeng 3 & Juan Tan 3 & Yunfei Long 4 & Yi Wang 3 Received: 5 August 2019 / Accepted: 6 December 2019 # Springer-Verlag GmbH Austria, part of Springer Nature 2020
Abstract Oxidative etching is an effective approach to control the morphology of nanomaterials. Taking silver nanocrystals (AgNCs) as an example, oxidative etching-directed morphological transformation from a triangular prism shape to a disk shape is achieved and then applied to the determination of captopril. As a mediator, trace amount of halides play important roles in the shape-controlled evolution of AgNCs. Etching causes the color of the triangular silver nanoprims (AgNPRs) to change from blue to yellow on formation of round nanodisks. On addition of captopril, the oxidative etching of the AgNPRs is prevented owing to the protection by the drug via Ag-S bonding. In this case, the solution color does not change. This finding was used to design an assay of captopril that has a linear response in the 10–600 nM concentration range and a 2 nM limit of detection. This method also allows digital camera read-out. It was successfully applied to quality control of captopril in tablets. Keywords Metal nanoparticles . Localized surface plasmon resonance . Smartphone . Peak shift . Hypertension . Pharmaceutical analysis
Introduction Noble metal nanomaterials with unique localized surface plasmon resonance (LSPR) absorption have been widely used in optical sensing, catalysis, optical imaging, photothermal therapy and photovoltaic conversion [1–5]. Their LSPR can be well tailored since it has strong correlations to the size, geometric shape, composition and surface state of noble metal nanocrystals. Thus, controlling these parameters is significant for engineering their LSPR and thereby strengthening the Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00604-019-4071-8) contains supplementary material, which is available to authorized users. * Yi Wang [email protected] 1
College of Pharmacy, Chongqing Medical University, Chongqing 400016, China
2
Children’s Hospital of Chongqing Medical University, Chongqing 400014, China
3
College of Chemistry, Chongqing Normal University, Chongqing 401331, China
4
School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, Hunan, China
performance in various applications. Oxidative etching is one of the mightiest ways in the shape/crystallinity control of the noble metal nanoparticles. It refers to the zerovalent metal species such as atoms, clusters and nanocrystals are able to be oxidized back to metal ions in air with the aid of an etchant [6]. As a result, the type of crystal structure, morphological and size distributions of the final products can be altered. For example, Xia et al. found that the etchant of Cl−/O2 or Fe3+/O2 pair was able to remove metal seeds twin defects (e
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