Comparative Genomics Methods and Protocols
This volume provides broad coverage of computational and mathematical techniques and concepts related to the field of comparative genomics. The topics covered in the chapters range from those concerned with general techniques and concepts that apply to al
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João C. Setubal Jens Stoye Peter F. Stadler Editors
Comparative Genomics Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences, University of Hertfordshire, Hatfield, Hertfordshire AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Comparative Genomics Methods and Protocols
Edited by
João C. Setubal Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP, Brazil
Jens Stoye Faculty of Technology and Center for Biotechnology (CeBiTec), Bielefeld University, Bielefeld, Germany
Peter F. Stadler Bioinformatics Group, Department of Computer Science, Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany
Editors Joa˜o C. Setubal Department of Biochemistry Institute of Chemistry University of Sa˜o Paulo Sa˜o Paulo, SP, Brazil
Jens Stoye Faculty of Technology and Center for Biotechnology (CeBiTec) Bielefeld University Bielefeld, Germany
Peter F. Stadler Bioinformatics Group Department of Computer Science Interdisciplinary Center for Bioinformatics University of Leipzig Leipzig, Germany
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-7461-0 ISBN 978-1-4939-7463-4 (eBook) https://doi.org/10.1007/978-1-4939-7463-4 Library of Congress Control Number: 2017960177 © Springer Science+Business Media LLC 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Cover image: Cover image design by Georges Hattab Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer ScienceþBusiness Media, LLC The registered company address is: 233 Spring St, New York, NY 10013, U.S.A.
Preface Since the rise of genetics and molecular biology during the twentieth century, a high potential was seen in the benefits of a better understandin
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