Current Topics in Microbiology and Immunology Volume 73

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73 Edited by W. Arber, Basle . W. Henle, Philadelphia. P. H. Hofschneider, Martinsried J. H. Humphrey, London' N. K.Jerne, Basle . P. KoJdovsky, Philadelphia H.Koprowski, Philadelphia' O. Maalge, Copenhagen· R. Rott, GieJfen . H. G.Schweiger, Wilhelmshaven . M. Sela, Rehovot . L. Syrucek, Prague· P. K. Vogt, Los Angeles

With 22 Figures

Springer-Verlag Berlin. Heidelberg. New York 1976

ISBN-13: 978-3-642-66308-6 001: 10.1007/978-3-642-66306-2

e-ISBN-13: 978-3-642-66306-2

This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Under § 54 of the German Copyright Law where copies are made for other private use, a fee is payable to the publisher, the amount of the fee to be determined by agreement with the publisher. © by Springer-Verlag, Berlin· Heidelberg 1976. Library of Congress Catalog Card Number 15-12910.

Softcover reprint of the hardcover 1st edition 1976 The use of registered names, trademarks, etc. in this publication, does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Universitatsdruckerei H. Sturtz AG, Wiirzburg

Table of Contents EMERSON, S. U., Vesicular Stomatitis Virus: Structure and Function of Virion Components . . . . . . . . . . . . . . . . . . . .

1

MARTIN, M.A., and KHOURY, G., Integration of DNA Tumor Virus Genomes . . . . . . . . . . . . . . . . . . . . . . . . . .

35

LEVINE, A. J., VAN DER VLIET, P. C., and SUSSENBACH, ]. S., The Replication of Papovavirus and Adenovirus DNA . . . . . . . . . .

67

WESTPHAL, H., In vitro Translation of Adenovirus Messenger RNA.

125

HEHLMANN, R, RNA Tumor Viruses and Human Cancer

141

Subject Index. . . . . . . . . . . . . . . . . . .

217

Vesicular Stomatitis Virus: Structure and Function of Virion Components S. U.

EMERSON l

With 4 Figures

Table of Contents I. Introduction II. Envelope A. Lipids . B. Identification of Protein Components . C. Location of G and M Proteins 1. Differential Solubilities. 2. Biochemical Assays . . . 3. Immunological Data. . . D. Attachment of G Protein to the Envelope. E. Immunology and Biochemical Composition of 1. Glycoprotein . . . . . . . . . . . . . a) Immunology. . . . . . . . . . . . b) Biochemical Analysis . . . . . . . . c) Composition of the G Protein From VS 2. M Protein . . . a) Immunology. . . . . . . . b) Biochemistry. . . . . . . . F. Functions of the G and M Proteins

the Envelope Proteins . . . . . . . . . . . . . . . . . . New Jersey.

III. Ribonucleocapsid . . . A. Virion RNA. . . . . . . . . . . B. Protein Components . . . . . . . C. Biochemistry and Immunology of the Ribonucleocapsid Proteins D. Functions of Ribonucleocapsid Proteins 1. N Protein 2. L Protein . . . . . . 3. NS Protein. . . . . . E. The Nucleocapsid Complex F. Polyadenylate Synthesis