Down-regulation of miR-200c associates with poor prognosis of oral squamous cell carcinoma
- PDF / 711,019 Bytes
- 7 Pages / 595.276 x 790.866 pts Page_size
- 24 Downloads / 176 Views
ORIGINAL ARTICLE
Down‑regulation of miR‑200c associates with poor prognosis of oral squamous cell carcinoma Jian Song1 · Nian Zhang1 · Lideng Cao1 · Di Xiao2 · Xingchen Ye1 · En Luo1 · Zhuang Zhang1 Received: 9 January 2020 / Accepted: 20 February 2020 © Japan Society of Clinical Oncology 2020
Abstract Background MicroRNAs (miRNAs) are considered as promising cancer biomarkers. The aim of the present study is to investigate the prognostic significance of miR-200c in patients with oral squamous cell carcinoma (OSCC). Materials and methods Quantitative real-time PCR (qRT-PCR) was used to determine the expression levels of miR-200c in 204 pairs of OSCC and adjacent noncancerous. Correlations between miR-200c expression levels and clinicopathological characteristics were investigated. Survival analysis was performed using the Kaplan–Meier method and log-rank test. Multivariate analysis of the prognostic factors was performed with a Cox proportional hazards regression model. Results The expression of miR-200c was significantly down-regulated in OSCC tissues compared with adjacent non-tumor tissues (p
Data Loading...
