Developing a versatile electrochemical platform with optimized electrode configuration through screen-printing technolog
- PDF / 1,725,599 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 85 Downloads / 141 Views
Developing a versatile electrochemical platform with optimized electrode configuration through screen-printing technology toward glucose detection Xiao Li 1
&
Man Zhang 1 & Yujie Hu 1 & Jian Xu 1 & Dongke Sun 1 & Tao Hu 1 & Zhonghua Ni 1
Accepted: 27 September 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Rapid on-site detection of glucose has been attracting considerable attention nowadays. Screen-printed electrodes (SPEs) were assessed as ideal detection platforms due to their advantages such as, disposability, portability, ease of miniaturization, and mass production. The topology and shape of electrodes have a crucial impact on their electrical conductivity and electrochemical properties. In this study, a versatile electrochemical platform with optimized three-electrode configuration was developed through screen-printing technology. Three types of SPEs were prepared, and their electrocatalytic properties toward glucose detection were investigated. Based on this platform, both enzyme-based (denoted as GOD/rGO) and non-enzymatic (denoted as Co@MoS2/rGO) bioactive compounds were deposited on the working electrode of the circular SPE through simply drop-casting, respectively. Their morphology was characterized through scanning electron microscopy (SEM). Cycle sweep voltammetry was used to study the electrocatalytic activity of these biosensors. The circular SPE exhibited satisfying electrochemical redox activity and much higher sensitivity towards glucose detection, which rendered it a promising candidate for point-of-care detection. Keywords Screen-printed electrode . Electrochemical . Glucose detection . Point-of-care
1 Introduction As a crucial biological indicator, blood glucose level is associated with heart disease, diabetes mellitus, kidney dysfunction, stroke, etc., of which both the diagnosis and treatment require a precise and quick determination of blood glucose level. A centerpiece in the successful platform is the compromise between the analytical figures of merit and some practical aspects regarding the robustness, promptness, operational simplicity and cost. Commonly used methods for glucose sensing include electrochemical methods (Wang et al. 2008), colorimetry (Morikawa et al. 2002), conductometry (Miwa Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10544-020-00527-y) contains supplementary material, which is available to authorized users. * Tao Hu [email protected] * Zhonghua Ni [email protected] 1
School of Mechanical Engineering, and Jiangsu Key Laboratory for Design and Manufacture of Micro–Nano Biomedical Instruments, Southeast University, Nanjing 211189, China
et al. 1994), optical methods (Mansouri and Schultz 1984), and fluorescent spectroscopy (Pickup et al. 2005). Electrochemical biosensors are identified as one of the most effective tools for glucose analysis with attractive advantages including high selectivity and sensitivity, low production cost, simple instrumentation, easy operation, and time
Data Loading...
