Electrochemical sensing of histamine using a glassy carbon electrode modified with multiwalled carbon nanotubes decorate
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ORIGINAL PAPER
Electrochemical sensing of histamine using a glassy carbon electrode modified with multiwalled carbon nanotubes decorated with Ag-Ag2O nanoparticles Nutthaya Butwong 1
&
Jariya Khajonklin 1 & Atitaya Thongbor 1 & John H. T. Luong 2
Received: 15 May 2019 / Accepted: 19 September 2019 # Springer-Verlag GmbH Austria, part of Springer Nature 2019
Abstract A glassy carbon electrode (GCE) was modified with a nanocomposite consisting of multiwalled carbon nanotubes (MWCNTs) loaded with silver-argentous oxide nanoparticles (Ag-Ag2O). The electrode is shown as a viable tool for sensing histamine using differential pulse voltammetry (DPV). The modified GCE, best operated at a potential of 0.97 V (vs. Ag/AgCl) shows higher electrocatalytic activity compared to GCEs modified with MWCNTs or Ag-Ag2O only. Under the optimum conditions, the detection limit is 2 μg⋅L−1 (0.18 μM) and the response is linear in the 5 mg⋅L−1 to 200 mg⋅L−1 histamine concentration range. Sodium chloride, putrescine and cadaverine, commonly present in biological samples and foods, do not interfere. Other performance features include good recoveries, fabrication reproducibility and operational/storage stability. The modified GCE was applied for determination of histamine in fish sauce samples. Keywords Silver-argentous oxide nanoparticles . MWCNTs . Histamine . Electrochemical sensing
Introduction Histamine (HIS) serves as an indicator of food poisoning and plays an important role in various biological processes [1]. The low HIS content in foods and sauces is not a serious concern because it is usually discharged from the body within a few hours. At high concentrations, however, HIS causes an allergy-like syndrome called scombrotoxin fish poisoning (SFP) [1]. The body metabolizes histamine to Nmethylhistamine or imidazole acetaldehyde by the catalytic actions of histamine N-methyltransferase and diamine oxidase Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00604-019-3860-4) contains supplementary material, which is available to authorized users. * Nutthaya Butwong [email protected] 1
Applied Chemistry Department, Faculty of Sciences and Liberal Arts, Rajamangala University of Technology Isan, 744, Suranarai Rd, Nakhon Ratchasima 30000, Thailand
2
Innovative Chromatography Group, Irish Separation Science Cluster (ISSC), School of Chemistry and the Analytical & Biological Chemistry Research Facility (ABCRF), University College Cork, Cork T12YT20, Ireland
(DAO), respectively. The subsequent catalysis of Nmethylhistamine by DAO and aldehyde dehydrogenase (ADH) results in N-methyl imidazole acetaldehyde and Nmethyl imidazole acetate. Similarly, imidazole acetaldehyde is further metabolized to imidazole acetate by ADH [2]. The intake of foods containing HIS affects blood vessels and smooth muscles, which are dependent upon the individual’s HIS intolerance [2]. Mild to severe intoxication occurs if the histamine quantities are above 100 mg and 1000 mg, particularly, from the consumption of
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