Docetaxel
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Bullous vesicant-type reaction: case report A 54-year-old woman developed bullous vesicant-type reaction while receiving docetaxel for undifferentiated uterine sarcoma. The woman was diagnosed with undifferentiated uterine sarcoma. She started receiving IV infusions of docetaxel on day 8 [dosage not stated] and gemcitabine on day 1 and day 8 along with premeditations. After starting the therapy with docetaxel, she developed generalized erythema with a sensation of heat and flushing. The infusion was discontinued. She also developed mild chest tightness, increased work of breathing and localized urticaria over the left forearm. The woman was treated with diphenhydramine and dexamethasone. Within 30 minutes of treatment, her clinical condition returned to baseline. Docetaxel and gemcitabine infusions were resumed and the woman completed the infusions without any other adverse reactions. Nine days later, she again presented with bullous reaction on her left arm skin following the tract of the vein, in which the drugs were infused. Physical examination showed tense, large painful bullae which filled with serous fluid on a nonerythematous base. She was treated with dressed polymixin-B/bacitracin, prednisone and hydrocortisone. Her lab tests showed neutropenia. After treatment, bullae lesion had resolved with residual hyperpigmentation. Following this reaction, docetaxel and gemcitabine was switched to single agent doxorubicin. Su J, et al. Bullous vesicant-type reaction to docetaxel along the venous tract: A case report. Gynecologic Oncology Reports 34: 100640, Nov 2020. Available from: URL: 803508117 http://doi.org/10.1016/j.gore.2020.100640
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Reactions 17 Oct 2020 No. 1826
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