Docetaxel
- PDF / 184,410 Bytes
- 1 Pages / 623.591 x 841.847 pts Page_size
- 85 Downloads / 185 Views
1
★
Meibomianitis and chalazion (first report) in an elderly patient: case report A 71-year-old man developed Meibomianitis with chalazion formation while receiving docetaxel for prostate cancer. The man had been diagnosed with metastatic prostate cancer in March 2005 and initially received bicalutamide, leuprorelin [leuprolide] and zoledronic acid. In December 2005, after disease progression and bicalutamide withdrawal, he started receiving IV docetaxel 35 mg/m2/week (with a break every fourth week) and prednisone. In March 2006, he presented with irritation and redness of his right eye, which was thought to be conjunctivitis. Docetaxel was suspended and ocular drops of a sulfonamide* were prescribed, with instructions to present for follow-up in 2 weeks. During this time, the man developed a painless, slow-growing right lower eyelid mass accompanied by substantial irritation and lacrimation in his right eye. On examination, he had a well circumscribed, raised, red nodule in his lower eyelid with injection of his right scleral conjunctiva. A metastasis was suspected and he underwent an excisional biopsy of the lesion; however, histological analysis was consistent with a chalazion. As his prostate-specific antigen level had increased following docetaxel interruption, treatment was restarted at a dosage of 60 mg/m2 every 3 weeks. He developed no further eyelid lesions over five subsequent docetaxel cycles, but experienced continued mild lacrimation, for which he received conservative treatment. Author comment: "[W]e suggest that the chalazion was due to Meibomian duct inflammation induced by docetaxel. . . The mechanism of canalicular stenosis is postulated to be secondary to secretion of the chemotherapeutic agent in the tear film and fibrosis of the canaliculi from direct contact with the drug." * specific sulfonamide not stated Gupta S, et al. Docetaxel-induced Meibomian duct inflammation and blockage leading to chalazion formation. Prostate Cancer and Prostatic Diseases 10: 801079690 396-397, No. 4, Dec 2007 - USA
» Editorial comment: A search of AdisBase, Medline and Embase did not reveal any previous case reports of meibomianitis or of chalazion associated with docetaxel. The WHO Adverse Drug Reactions database contained no reports of meibomianitis associated with docetaxel.
0114-9954/10/1186-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 26 Jan 2008 No. 1186
Data Loading...
